Much remains unknown about the roles of CD4+ T helper cells in shaping localized memory
B cell and CD8+ T cell immunity in the mucosal tissues. Here, we report that lung T helper …

Tissue-resident memory T (Trm) cells provide enhanced protection against infection at
mucosal sites. Here we found that CD4+ T cells are important for the formation of functional …

Tissue-resident memory T cells (T RM) provide optimal defense at the sites of infection, but
signals regulating their development are unclear, especially for CD4 T cells. Here we …

Influenza is a deadly and costly infectious disease, even during flu seasons when an
effective vaccine has been developed. To improve vaccines against respiratory viruses, a …

Nasal epithelial tissue of the upper respiratory tract is the first site of contact by inhaled
pathogens such as influenza virus. We show that this region is key to limiting viral spread to …

CD4+ lung-resident memory T cells (TRM) generated in response to influenza infection
confer effective protection against subsequent viral exposures. Whether these cells can be …

Tissue-resident memory CD8+ T (TRM) cells that develop in the epithelia at portals of
pathogen entry are important for improved protection against re-infection. CD8+ TRM cells …

The human lung harbors a large population of resident memory T cells (Trm cells). These
cells are perfectly positioned to mediate rapid protection against respiratory pathogens such …

Abstract Resident memory CD8 T (TRM) cells in the lung parenchyma (LP) and airways
provide heterologous protection against influenza virus challenge. However, scant …

The extent to which tissue-specific viral infections generate memory T cells specifically
adapted to and maintained within the target infection site is unknown. Here, we show that …