[HTML][HTML] Early precursor T cells establish and propagate T cell exhaustion in chronic infection
DT Utzschneider, SS Gabriel, D Chisanga… - Nature …, 2020 - nature.com
CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted'state
associated with elevated expression of inhibitory receptors, including PD-1, and impaired …
associated with elevated expression of inhibitory receptors, including PD-1, and impaired …
BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection
Y Chen, RA Zander, X Wu, DM Schauder… - Nature …, 2021 - nature.com
During chronic viral infection, CD8+ T cells develop into three major phenotypically and
functionally distinct subsets: Ly108+ TCF-1+ progenitors, Ly108− CX3CR1− terminally …
functionally distinct subsets: Ly108+ TCF-1+ progenitors, Ly108− CX3CR1− terminally …
[HTML][HTML] 'Stem-like' precursors are the fount to sustain persistent CD8+ T cell responses
D Zehn, R Thimme, E Lugli, GP de Almeida… - Nature …, 2022 - nature.com
Virus-specific CD8+ T cells that differentiate in the context of resolved versus persisting
infections exhibit divergent phenotypic and functional characteristics, which suggests that …
infections exhibit divergent phenotypic and functional characteristics, which suggests that …
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans
T cell exhaustion is an induced state of dysfunction that arises in response to chronic
infection and cancer. Exhausted CD8+ T cells acquire a distinct epigenetic state, but it is not …
infection and cancer. Exhausted CD8+ T cells acquire a distinct epigenetic state, but it is not …
[HTML][HTML] Transcriptional regulatory network for the establishment of CD8+ T cell exhaustion
W Seo, C Jerin, H Nishikawa - Experimental & molecular medicine, 2021 - nature.com
Chronic infection with persistent antigenic stimulation results in the generation of exhausted
CD8+ T cells, which are considered defective effector CD8+ T cells, and thus compromises …
CD8+ T cells, which are considered defective effector CD8+ T cells, and thus compromises …
Exhausted CD8+ T cells face a developmental fork in the road
Reinvigorating the function of exhausted CD8+ T cells during chronic viral infection and
cancer is a major goal of current immunotherapy regimens. Here, we discuss recent …
cancer is a major goal of current immunotherapy regimens. Here, we discuss recent …
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells
During chronic infection and cancer, a self-renewing CD8+ T cell subset maintains long-term
immunity and is critical to the effectiveness of immunotherapy. These stem-like CD8+ T cells …
immunity and is critical to the effectiveness of immunotherapy. These stem-like CD8+ T cells …
[HTML][HTML] BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers
R Roychoudhuri, D Clever, P Li, Y Wakabayashi… - Nature …, 2016 - nature.com
T cell antigen receptor (TCR) signaling drives distinct responses depending on the
differentiation state and context of CD8+ T cells. We hypothesized that access of signal …
differentiation state and context of CD8+ T cells. We hypothesized that access of signal …
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
Abstract Exhausted CD8+ T (Tex) cells in chronic infections and cancer have limited effector
function, high co-expression of inhibitory receptors and extensive transcriptional changes …
function, high co-expression of inhibitory receptors and extensive transcriptional changes …
[HTML][HTML] Transcription factor IRF4 promotes CD8+ T cell exhaustion and limits the development of memory-like T cells during chronic infection
During chronic stimulation, CD8+ T cells acquire an exhausted phenotype characterized by
expression of inhibitory receptors, down-modulation of effector function, and metabolic …
expression of inhibitory receptors, down-modulation of effector function, and metabolic …