Abstract C57BL/6 (B6). FcγRIIb−/−. Yaa mice spontaneously develop lethal lupus nephritis.
To define the cell type–specific role of FcγRIIb in Yaa-associated lupus, we established B …

FcγRIIB is an inhibitory receptor expressed throughout B cell development. Diminished
expression or function is associated with lupus in mice and humans, in particular through an …

Objective Fcγ receptor II b (Fcγ RII b) is an essential negative regulator of B cells that blocks
B cell receptor (BCR) signaling and triggers c‐Abl–dependent apoptosis of B cells. Fcγ RII b …

Immune complex (IC)-mediated tissue inflammation is controlled by stimulatory and
inhibitory IgG Fc receptors (FcγRs). Systemic lupus erythematosus is a prototype of IC …

Data suggests that modulation of FcγRIIB expression represents a significant risk factor for
the development of autoimmunity. In this study, we investigated this notion in mice that …

Engagement of the low-affinity Ab receptor FcγRIIb downregulates B cell activation, and its
dysfunction is associated with autoimmunity in mice and humans. We engineered the Fc …

FcγRIIB-deficient mice generated in 129 background (FcγRIIB 129−/−) if back-crossed into
C57BL/6 background exhibit a hyperactive phenotype and develop lethal lupus. Both in …

Abstract FcγRIIb (CD32B, Online Mendelian Inheritance in Man 604590), an IgG FcR with a
tyrosine-based inhibitory motif, plays a critical role in the balance of tolerance and …

Crosslinking of Fc γ receptor II B (FcγRIIB) and the BCR by immune complexes (IC) can
downregulate antigen‐specific B‐cell responses. Accordingly, FcγRIIB deficiencies have …

Abstract Background The inhibitory Fc receptor, FcγRIIB, has emerged as a key negative
regulator of B cell activation and as such is predicted to play an essential role in controlling …