Galectins are differentially expressed in supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas, and significantly modulate …

I Camby, N Belot, S Rorive, F Lefranc… - Brain …, 2001 - Wiley Online Library
Galectins, a family of mammalian lectins with specificity to β‐galactosides, are involved in
growth‐regulatory mechanisms and cell adhesion. A relationship is assumed to exist …

Galectin‐1 is highly expressed in human gliomas with relevance for modulation of invasion of tumor astrocytes into the brain parenchyma

S Rorive, N Belot, C Decaestecker, F Lefranc… - Glia, 2001 - Wiley Online Library
Protein (lectin)‐carbohydrate interaction is supposed to be relevant for tumor cell behavior.
The aims of the present work are to investigate whether galectin‐1 modulates …

Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPases

I Camby, N Belot, F Lefranc, N Sadeghi… - … of Neuropathology & …, 2002 - academic.oup.com
We show that high-grade astrocytic tumors with high levels of galectin-1 expression are
associated with dismal prognoses. The immunohistochemical analysis of galectin-1 …

Galectins and gliomas

M Le Mercier, S Fortin, V Mathieu, R Kiss… - Brain …, 2010 - Wiley Online Library
Malignant gliomas, especially glioblastomas, are associated with a dismal prognosis.
Despite advances in diagnosis and treatment, glioblastoma patients still have a median …

Role of galectin-1 in migration and invasion of human glioblastoma multiforme cell lines

TY Jung, S Jung, HH Ryu, YI Jeong, YH Jin… - Journal of …, 2008 - thejns.org
Object Galectin-1 is highly expressed in motile cell lines. The authors investigated whether
galectin-1 actually modulates the migration and invasion of human glioblastoma multiforme …

Galectin‐3 and galectin‐3‐binding site expression in human adult astrocytic tumours and related angiogenesis

Gordower, Decaestecker, Kacem… - Neuropathology and …, 1999 - Wiley Online Library
Using computer‐assisted microscopy, the present work aimed to quantitatively characterize
the level of the histochemically detectable expression of galectin‐3 and galectin‐3‐binding …

Galectin-3: cellular distribution and correlation with WHO-grade in human gliomas

HM Strik, MH Deininger, B Frank… - Journal of neuro …, 2001 - Springer
In order to elucidate the reason for conflicting results that have been published previously on
galectin-3 expression in human gliomas, we used single labeling and double labeling …

Galectin-1 expression in human glioma cells: modulation by ionizing radiation and effects on tumor cell proliferation and migration

HM Strik, K Schmidt, P Lingor, L Tönges… - Oncology …, 2007 - spandidos-publications.com
Galectins are evolutionarily conserved β-galactoside-binding lectins which recognize
specific glycoconjugates on the cell surface and the extracellular matrix. Accumulating …

Multifaceted role of galectin-3 on human glioblastoma cell motility

C Debray, P Vereecken, N Belot, P Teillard… - Biochemical and …, 2004 - Elsevier
Astrocytic tumors' aggressiveness results from an imbalance between cell proliferation and
cell death favoring growth, but also from the propensity of tumor cells to detach from the …

Expression of the endogenous galactose‐binding protein galectin‐3 correlates with the malignant potential of tumors in the central nervous system

RS Bresalier, PS Yan, JC Byrd… - … International Journal of …, 1997 - Wiley Online Library
BACKGROUND The 31‐kilodalton β‐galactoside‐binding protein galectin‐3 has been
associated with cellular transformation and metastasis. Because neural tissues contain large …