[HTML][HTML] Gastrodin ameliorates depressive-like behaviors via modulating gut microbiota in CUMS-induced mice

Y Zhao, S Qin, Z Yang, Y Lu, Z Ma, X Ping… - Behavioural Brain …, 2024 - Elsevier
Purpose Depression is a psychiatric disorder and the treatment of depression is an urgent
problem that need to be solved. Gastrodin (GAS) is a Traditional Chinese Medicine from an …

Gastrodin From Gastrodia elata Enhances Cognitive Function and Neuroprotection of AD Mice via the Regulation of Gut Microbiota Composition and Inhibition of …

OB Fasina, J Wang, J Mo, H Osada, H Ohno… - Frontiers in …, 2022 - frontiersin.org
Gastrodin (Gas) is known to exhibit neuroprotective effects in Alzheimer's disease (AD).
However, the detailed mechanism of action is still unclear. In the present study, we focused …

Altered fecal metabolites and colonic glycerophospholipids were associated with abnormal composition of gut microbiota in a depression model of mice

X Gong, C Huang, X Yang, J Chen, J Pu… - Frontiers in …, 2021 - frontiersin.org
The microbiota–gut–brain axis has been considered to play an important role in the
development of depression, but the underlying mechanism remains unclear. The …

[HTML][HTML] CUMS and dexamethasone induce depression-like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation

J Wu, J Li, C Gaurav, U Muhammad, Y Chen… - General …, 2021 - ncbi.nlm.nih.gov
Background Although the link between gut microbiota and depression has been suggested,
changes of gut microbiota vary largely among individuals with depression. Aims Explore the …

Characteristics of Oral-Gut Microbiota in Model Rats with CUMS-Induced Depression

Y Li, P Liu - Neuropsychiatric Disease and Treatment, 2024 - Taylor & Francis
Purpose The diversity and composition of the oral and gut microbiota of depressed rats were
analyzed to explore the microbiological etiology of major depressive disorder (MDD) …

Gut microbiota regulates depression-like behavior in rats through the neuroendocrine-immune-mitochondrial pathway

S Liu, R Guo, F Liu, Q Yuan, Y Yu… - … disease and treatment, 2020 - Taylor & Francis
Purpose Gut microbiota affects various physiological functions in the host and has crucial
effects on the nervous system. There is increasing evidence of a correlation between gut …

Gut microbiota regulates mouse behaviors through glucocorticoid receptor pathway genes in the hippocampus

Y Luo, B Zeng, LI Zeng, X Du, B Li, R Huo, L Liu… - Translational …, 2018 - nature.com
Gut microbiota has an important role in the immune system, metabolism, and digestion, and
has a significant effect on the nervous system. Recent studies have revealed that abnormal …

Tryptophan metabolism as bridge between gut microbiota and brain in chronic social defeat stress-induced depression mice

J Xie, W Wu, J Chen, Q Zhong, D Wu, L Niu… - Frontiers in Cellular …, 2023 - frontiersin.org
Backgrounds Gut microbiota plays a critical role in the onset and development of
depression, but the underlying molecular mechanisms are unclear. This study was …

Anti-depressive-like and cognitive impairment alleviation effects of Gastrodia elata Blume water extract is related to gut microbiome remodeling in ApoE−/− mice …

HS Huang, YE Lin, S Panyod, RA Chen, YC Lin… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacology relevance Gastrodia elata Blume (GE) is a traditional Chinese
dietary therapy used to treat neurological disorders. Gastrodia elata Blume water extract …

Gastrodia elata Blume water extract modulates neurotransmitters and alters the gut microbiota in a mild social defeat stress‐induced depression mouse model

YJ Huang, LXC Choong, S Panyod, YE Lin… - Phytotherapy …, 2021 - Wiley Online Library
Gastrodia elata Blume has multiple bioactive functions, such as antioxidant and
antidepressant activities, immune modulation, neuroplasticity, and neuroprotection. We …