While immunotherapy is typically reserved for cancer patients with a high mutational burden,
neoantigens produced from post-transcriptional regulation provide a possible untapped …

Cancer transcriptomes frequently exhibit RNA dysregulation. As the resulting aberrant
transcripts may be translated into cancer-specific proteins, there is growing interest in …

Synthetic mRNA provides a template for the synthesis of any given protein, protein fragment
or peptide and lends itself to a broad range of pharmaceutical applications, including …

Cancer immunotherapy has revolutionized oncology practice. However, current protein and
cell therapy tools used in cancer immunotherapy are far from perfect, and there is room for …

The past few decades have witnessed the remarkable progress of cancer immunotherapy.
Neoantigens, also known as tumor-specific antigens, are novel antigens originating from …

Immunotherapeutic manipulation of the antitumor immune response offers an attractive
strategy to target genomic instability in cancer. A subset of tumor-specific somatic mutations …

Vaccines are the most impactful medicines to improve health. Though potent against
pathogens, vaccines for cancer remain an unfulfilled promise. However, recent advances in …

Simple Summary Cancer onset and progression are promoted by high deregulation of the
immune system. Recently, major advances in molecular and clinical cancer immunology …

Advances in nucleic acid sequencing technologies have revolutionized the field of
genomics, allowing the efficient targeting of mutated neoantigens for personalized cancer …

Cancer is a leading cause of death worldwide, accounting for millions of deaths every year.
Immunotherapy is a groundbreaking approach for treating cancer through harnessing the …