[HTML][HTML] Multifunctional metallothioneins as a target for neuroprotection in Parkinson's disease

I Miyazaki, M Asanuma - Antioxidants, 2023 - mdpi.com
Parkinson's disease (PD) is characterized by motor symptoms based on a loss of
nigrostriatal dopaminergic neurons and by non-motor symptoms which precede motor …

Metallothioneins and the central nervous system: From a deregulation in neurodegenerative diseases to the development of new therapeutic approaches

S Bolognin, B Cozzi, P Zambenedetti… - Journal of Alzheimer's …, 2014 - content.iospress.com
Metallothioneins (MT) are a family of proteins actively involved in metal detoxification and
storage as well as in prevention of free-radical damage. Changes in the levels of MT have …

[PDF][PDF] Metallothioneins as early and sensitive biomarkers of redox signaling in neurodegenerative disorders

S Sharma, M Ebadi - The IIOAB Journal, 2011 - Citeseer
ABSTRACT Metallothioneins (MT-1-4) are versatile, redox-sensitive, low molecular weight
cysteine-rich, metal binding proteins, which were discovered for the first time by Marghoshes …

Roles and therapeutic potential of metallothioneins in neurodegenerative diseases

I Hozumi - Current pharmaceutical biotechnology, 2013 - ingentaconnect.com
Metallothionein (MT) is a small molecular and multi-functional protein containing four atoms
of copper (Cu) and three atoms of zinc (Zn) per molecule. It was isolated from the horse …

Significance of metallothioneins in aging brain

S Sharma, M Ebadi - Neurochemistry International, 2014 - Elsevier
Aging is an inevitable biological process, associated with gradual and spontaneous
biochemical and physiological changes, and increased susceptibility to diseases. Chronic …

Neuroprotective and neuroregenerative properties of metallothioneins

CRA Santos, A Martinho, T Quintela, I Gonçalves - IUBMB life, 2012 - Wiley Online Library
Metallothioneins (MTs) are low‐molecular weight cysteine‐and metal‐rich proteins with
unquestionable metal binding capacity, antioxidant and anti‐inflammatory properties, and a …

[HTML][HTML] Metallothionein, copper and alpha-synuclein in alpha-synucleinopathies

Y Okita, AN Rcom-H'cheo-Gauthier… - Frontiers in …, 2017 - frontiersin.org
Metallothioneins (MTs) are proteins that function by metal exchange to regulate the
bioavailability of metals, such as zinc and copper. Copper functions in the brain to regulate …

Zinc–metallothionein: a potential mediator of antioxidant defence mechanisms in response to dopamine-induced stress

JK Eibl, Z Abdallah, GM Ross - Canadian journal of physiology …, 2010 - cdnsciencepub.com
Clinically, Parkinson's disease (PD) is a neurodegenerative disorder characterized by the
development of tremors and rigidity that is found primarily in patients over the age of 50. At …

Metallothionein in brain disorders

D Juárez-Rebollar, C Rios, C Nava-Ruíz… - Oxidative medicine …, 2017 - Wiley Online Library
Metallothioneins are a family of proteins which are able to bind metals intracellularly, so their
main function is to regulate the cellular metabolism of essential metals. There are 4 major …

Neuroprotective effects of metallothionein against rotenone-induced myenteric neurodegeneration in parkinsonian mice

S Murakami, I Miyazaki, N Sogawa, K Miyoshi… - Neurotoxicity …, 2014 - Springer
Parkinson's disease (PD) is a neurodegenerative disease with motor symptoms as well as
non-motor symptoms that precede the onset of motor symptoms. Mitochondrial complex I …