Insulin resistance is a pathological state often associated with obesity, representing a major
risk factor for type 2 diabetes. Limited mechanism-based strategies exist to alleviate insulin …

Both adipocyte hyperplasia and hypertrophy are determinant factors for adipocyte
differentiation during the development of obesity. p21 WAF1/CIP1, a cyclin-dependent …

Adipose tissue inflammation and dysfunction are associated with obesity‐related insulin
resistance and diabetes, but mechanisms underlying this relationship are unclear. Although …

Increased insulin resistance and impaired insulin secretion are significant characteristics
manifested by patients with type 2 diabetes mellitus (T2DM). The degree and extent of these …

The insulin/insulin‐like growth factor‐1 signalling (IIS) pathway regulates cellular and
organismal metabolism and controls the rate of aging. Gain‐of‐function mutations in p110α …

Diet-induced obesity (DIO) predisposes individuals to insulin resistance, and adipose tissue
has a major role in the disease. Insulin resistance can be induced in cultured adipocytes by …

Insulin resistance drives the development of type 2 diabetes (T2D). In liver, diacylglycerol
(DAG) is a key mediator of lipid-induced insulin resistance. DAG activates protein kinase C ε …

Adipocyte hyperplasia is characteristic of some forms of human obesity, but the role of
adipocyte number in obesity and how normal adipocyte number is established are unclear …

Adipose precursor cells (APCs) exhibit regional variation in response to obesity, for unclear
reasons. Here, we reveal that HIFα-induced PDGFRβ signaling within murine white adipose …

Pancreatic cancer stem cells (PaCSCs) drive pancreatic cancer tumorigenesis,
chemoresistance and metastasis. While eliminating this subpopulation of cells would …