Rationale: Although epidemiological studies consistently show that chronic obstructive
pulmonary disease is associated with an increased risk of lung cancer, debate exists as to …

The relationship between smoking, lung cancer and airflow obstruction is recognised but it is
unclear whether the presence of minimal lung function damage constitutes an independent …

Rationale: Annual computed tomography (CT) is now widely recommended for lung cancer
screening in the United States, although concerns remain regarding the potential harms …

Objectives Several studies have identified airflow obstruction as a risk factor for lung cancer
independent of smoking history, but the risk associated with the presence of radiographic …

Importance Current eligibility criteria for lung cancer (LC) screening are derived from
randomised controlled trials and primarily based on age and smoking history. However, the …

Background There is increasing evidence that structural lung changes may be present
before the occurrence of airflow limitation as assessed by spirometry. This study investigated …

Context Smoking is a major risk factor for both cancer and chronic obstructive pulmonary
disease (COPD). Computed tomography (CT)–based lung cancer screening may provide an …

Background To study the relationship between emphysema, airflow obstruction, and lung
cancer in a high-risk population, we performed quantitative analysis of screening computed …

Rationale: To study the relationship between emphysema and/or airflow obstruction and
lung cancer in a high-risk population. Objective: We studied lung cancer related to …

Background Lung cancer is a leading cause of death and hospitalization for patients with
COPD. A detailed understanding of which clinical features of COPD increase risk is needed …