DNA methylation and transcriptome signatures of the PDCD1 gene in ankylosing spondylitis

Y Wu, Y Chen, X Sun, Y Deng, M Ni, F Pan - Genes & Immunity, 2023 - nature.com
Ankylosing spondylitis (AS) is an autoimmune-related inflammatory arthritis. The association
between the DNA methylation and mRNA expression of PDCD1 gene with the susceptibility …

Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis

J Hao, Y Liu, J Xu, W Wang, Y Wen, A He… - Arthritis Research & …, 2017 - Springer
Background Ankylosing spondylitis (AS) is a chronic rheumatic and autoimmune disease.
Little is known about the potential role of DNA methylation in the pathogenesis of AS. This …

Programmed cell death 10 can be used as a potential biomarker for ankylosing spondylitis diagnosis and treatment

WJ Ni, XM Leng - Spinal Cord, 2024 - nature.com
Abstract Study design Diagnostic study. Objective Programmed cell death 10 (PDCD10) is a
new versatile molecule involved in signal transduction regulation in angiogenesis and …

Evaluation of PD-1 Gene Expression Profile and Methylation of the Regulatory Regions in Patients with Ankylosing Spondylitis

N Soleimanifar, S Assaadiasl… - Iranian Journal of …, 2024 - iji.sums.ac.ir
Background: Ankylosing spondylitis (AS) is a chronic autoimmune disorder characterized by
the fusion of vertebral joints and axial arthritis. The programmed death-1 (PD-1) inhibitory …

Association of methylation level and transcript level in TRAF5 gene with ankylosing spondylitis: a case-control study

S Xu, X Gao, Y Ma, J Deng, S Xu, F Pan - Genes & Immunity, 2021 - nature.com
To explore the association between methylation level and transcript level of TNF receptor-
associated factor 5 (TRAF5) gene with ankylosing spondylitis (AS) in Chinese Han …

Study of Programmed Cell Death 1 (PDCD1) Gene Polymorphims in Iranian Patients with Ankylosing Spondylitis

N Soleimanifar, AA Amirzargar, M Mahmoudi… - Inflammation, 2011 - Springer
Ankylosing spondylitis (AS) is a chronic inflammatory disease, characterized by axial arthritis
in which the genetic–environmental factors seem to be involved in the pathogenesis of the …

Aberrant DNA Methylation Profile of Dickkopf-1 in Ankylosing Spondylitis

X Sun, Y Deng, M Ni, T Zhang, X Wang, Y Wu… - Biochemical …, 2024 - Springer
In recent years, the impact of methylation modifications on Dickkopf-1 (DKK1) in relation to
ankylosing spondylitis (AS) has remained elusive. Our objective was to investigate the …

PRICKLE1 gene methylation and abnormal transcription in Chinese patients with ankylosing spondylitis

T Zhou, X Wang, J Kong, L Yu, H Xie, F Wang, S Xu… - Immunobiology, 2023 - Elsevier
Background Ankylosing spondylitis (AS) is a common inflammatory arthritis without a
reliable biomarker. The role of methylation and mRNA expression of PRICKLE1 promoter in …

The programmed cell death 1 gene polymorphisms (PD 1.3 G/A, PD 1.5 C/T and PD 1.9 C/T) and susceptibility to ankylosing spondylitis: a meta-analysis

M Yang, Y Zou, Y Bai, M Li - Journal of Orthopaedic Science, 2015 - Springer
Objective The objective is to integrate all the eligible studies and investigate whether the
programmed cell death 1 (PDCD-1) gene polymorphisms (PD 1.3 G/A, PD 1.5 C/T, and PD …

Integrative blood-derived epigenetic and transcriptomic analysis reveals the potential regulatory role of DNA methylation in ankylosing spondylitis

M Xiao, X Zheng, X Li, X Wu, Y Huang, Q Wei… - Arthritis Research & …, 2022 - Springer
Background The currently known risk loci could explain a small proportion of the heritability
of ankylosing spondylitis (AS). Epigenetics might account for the missing heritability. We …