Heat shock proteins (Hsps) are molecular chaperones that also play important roles in the
activation of the heat shock response (HSR). The HSR is an evolutionary conserved and …

Induction of heat shock proteins (Hsps) is under investigation as treatment for
neurodegenerative disorders, yet many types of neurons, including motor neurons that …

Heat shock proteins (Hsps) comprise a heterogeneous group of highly conserved molecules
that are a critical component of proteostasis. Some Hsps are constitutively expressed in cells …

Heat shock proteins (HSPs) are families of molecular chaperones that play important
homeostatic functions in the central nervous system (CNS) by preventing protein misfolding …

Cells respond to protein-damaging (proteotoxic) stress by activation of the Heat Shock
Response (HSR). The HSR provides cells with an enhanced ability to endure proteotoxic …

The heat-shock response, one of the main pro-survival mechanisms of a living organism,
has evolved as the biochemical response of cells to cope with heat stress. The most well …

Historically, small heat shock proteins (sHSPs) have been extensively studied in the context
of being intracellular molecular chaperones. However, recent studies looking at the role of …

Hsp90 is a molecular chaperone with important roles in regulating pathogenic
transformation. In addition to its well-characterized functions in malignancy, recent evidence …

Members of the small heat shock protein (sHSP) family are molecular chaperones with a
critical role in the maintenance of cellular homeostasis under unfavorable conditions. The …

Neurodegenerative diseases including amyotrophic lateral sclerosis, Parkinson's disease,
Alzheimer's disease, and polyglutamine (polyQ) diseases are thought to be caused by …