Inter-organ crosstalk has gained increasing attention in recent times; however, the
underlying mechanisms remain unclear. In this study, we elucidate an endocrine pathway …

Obesity is a major cause of metabolic dysfunction-associated steatohepatitis (MASH) and is
characterized by inflammation and insulin resistance. Interferon-γ (IFNγ) is a pro …

Background and Aims Although knowledge regarding the pathogenesis of nonalcoholic fatty
liver disease (NAFLD) has profoundly grown in recent decades, the internal restrictive …

Nonalcoholic fatty liver disease (NAFLD) has become a worldwide epidemic. A large and
growing unmet therapeutic need has inspired numerous studies in the field. Integrating the …

Nonalcoholic steatohepatitis (NASH) is a key step in the progression of nonalcoholic fatty
liver (NAFL) to cirrhosis. However, the molecular mechanisms of the NAFL-to-NASH …

Nonalcoholic steatohepatitis (NASH) is an unmet clinical challenge due to the rapid
increase in its occurrence but the lack of approved drugs to treat it. Further unraveling of the …

Nonalcoholic fatty liver disease is a chronic condition involving steatosis, steatohepatitis and
fibrosis, and its progression remains unclear. Although the tetraspanin transmembrane 4 L …

Obesity is a major risk factor for the development of Nonalcoholic fatty liver disease
(NAFLD). We hypothesize that a dysfunctional subcutaneous white adipose tissue (scWAT) …

Summary Nuclear-erythroid-2-related factor 2 (Nrf2) is involved in the pathogenesis of
different liver diseases. Herein, we first demonstrated that Nrf2 expression was diminished in …

Background & Aims Non-alcoholic steatohepatitis (NASH) is associated with the
dysregulation of lipid metabolism and hepatic inflammation. The causal mechanism …