Melanotransferrin is a glycoprotein expressed at the cell membrane and secreted in the
extracellular environment. Recombinant truncated form of membrane-bound …

Abstract Melanotransferrin (MTf), the membrane-bound human melanoma antigen p97,
binds to plasminogen and stimulates its activation, thus regulating a crucial step involved in …

The activation of plasminogen at the cell surface is a crucial step in cell migration and
invasion. In the present study, the effect of membrane-bound melanotransferrin (mMTf), also …

Melanotransferrin is a member of the transferrin family, which is comprised of serum
transferrin, lactoferrin and ovotransferrin, and is highly expressed on melanoma cells …

The expression of melanotransferrin (MTf), a membrane-bound glycoprotein highly
expressed in melanomas, is correlated with tumor vascularization and progression …

We have previously demonstrated that human recombinant soluble melanotransferrin (hr-
sMTf) interacts with the single-chain zymogen pro urokinase-type plasminogen activator …

Melanotransferrin (MTf) or melanoma tumor antigen p97 is an iron (Fe) binding transferrin
homolog expressed highly on melanomas and at lower levels on normal tissues. It has been …

Tissue plasminogen activator (t-PA) is an extracellular serine protease that converts the
proenzyme plasminogen into the broad-spectrum substrate serine protease, plasmin …

Brain metastases are a common feature of malignant melanoma and are associated with
poor prognosis. Melanotransferrin (MTf), one of several antigens associated with the surface …

Tissue-type plasminogen activator (tPA) and its substrate plasminogen (Plg) are key
components in the fibrinolytic system. We have recently demonstrated, that truncated human …