Delivery of small interfering RNAs by nanovesicles for cancer therapy

S Pengnam, S Plianwong, B Yingyongnarongkul… - Drug Metabolism and …, 2022 - Elsevier
Small interfering ribonucleic acids (siRNAs) are originally recognized as an intermediate of
the RNA interference (RNAi) pathway. They can inhibit or silence various cellular pathways …

The “non-viral” approach for siRNA delivery in cancer treatment: a special focus on micelles and liposomes

G Navarro, S Essex, VP Torchilin - DNA and RNA Nanobiotechnologies in …, 2013 - Springer
Over the past two decades, small interfering RNA (siRNA) has gained widespread popularity
as an efficient tool for cancer therapy. Unfortunately, due to its inherent instability, the …

Recent advancements in the design of nanodelivery systems of siRNA for cancer therapy

DN Yadav, MS Ali, AM Thanekar, SV Pogu… - Molecular …, 2022 - ACS Publications
RNA interference (RNAi) has increased the possibility of restoring RNA drug targets for
cancer treatment. Small interfering RNA (siRNA) is a promising therapeutic RNAi tool that …

Targeting siRNAs in cancer drug delivery

MA Obeid, AAA Aljabali, W Alshaer, NB Charbe… - Advanced drug delivery …, 2021 - Elsevier
Small interfering RNA (siRNA) has been identified as a useful therapeutic resource in
cancer therapy. Molecular manipulation with siRNA has been reported to have high …

A comprehensive review of small interfering RNAs (siRNAs): mechanism, therapeutic targets, and delivery strategies for cancer therapy

J Zhang, B Chen, C Gan, H Sun, J Zhang… - International Journal of …, 2023 - Taylor & Francis
Small interfering RNA (siRNA) delivery by nanocarriers has been identified as a promising
strategy in the study and treatment of cancer. Short nucleotide sequences are synthesized …

Tumor‐targeting multifunctional nanoparticles for siRNA delivery: Recent advances in cancer therapy

SH Ku, K Kim, K Choi, SH Kim… - Advanced healthcare …, 2014 - Wiley Online Library
RNA interference (RNAi) is a naturally occurring regulatory process that controls
posttranscriptional gene expression. Small interfering RNA (siRNA), a common form of RNAi …

[HTML][HTML] Nanoparticles as drug delivery systems in cancer medicine: emphasis on RNAi-containing nanoliposomes

MR Díaz, PE Vivas-Mejia - Pharmaceuticals, 2013 - mdpi.com
Nanomedicine is a growing research field dealing with the creation and manipulation of
materials at a nanometer scale for the better treatment, diagnosis and imaging of diseases …

Nanoparticle-siRNA: A potential cancer therapy?

SWS Young, M Stenzel, Y Jia-Lin - Critical reviews in oncology/hematology, 2016 - Elsevier
Purpose To explore current developments in short interfering RNA (siRNA) delivery systems
in nanooncology, in particular nanoparticles that encapsulate siRNA for targeted treatment …

Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy

E Miele, GP Spinelli, E Miele, E Di Fabrizio… - International journal …, 2012 - Taylor & Francis
During recent decades there have been remarkable advances and profound changes in
cancer therapy. Many therapeutic strategies learned at the bench, including monoclonal …

Engineered polymeric nanoparticles to guide the cellular internalization and trafficking of small interfering ribonucleic acids

AE Arnold, P Czupiel, M Shoichet - Journal of Controlled Release, 2017 - Elsevier
Ribonucleic acid interference therapy is a promising cancer treatment, which uses small
interfering RNAs (siRNAs) to target and degrade messenger RNAs. Due to endogenous …