Hypoxia inducible factor‐1α gene polymorphism G1790A and its interaction with tobacco and alcohol consumptions increase susceptibility to hepatocellular …

PC Hsiao, MK Chen, SC Su, KC Ueng… - Journal of surgical …, 2010 - Wiley Online Library
Abstract Background and Objectives The aim of this study was to examine the potential
associations of two hypoxia inducible factor‐1α (HIF‐1α) gene polymorphisms, C1772T and …

Genetic polymorphisms in hypoxia-inducible factor-1a gene and its association with HBV-related hepatocellular carcinoma in a Chinese population

Y Liu, J Sui, L Zhai, S Yang, L Huang, L Huang, C Mo… - Medical Oncology, 2014 - Springer
Previous studies have demonstrated that hypoxia-inducible factor-1a (HIF-1a) may play a
vital role in the pathogenesis of hepatocellular carcinoma (HCC). However, the relationship …

[HTML][HTML] The association between hypoxia-inducible factor-1 α gene G1790A polymorphism and cancer risk: a meta-analysis of 28 case–control studies

Y Zhou, L Lin, Y Wang, X Jin, X Zhao, D Liu, T Hu… - Cancer Cell …, 2014 - Springer
Abstract Purpose Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor that
regulates the cellular adaptation to hypoxia. HIF-1α gene single nucleotide polymorphisms …

[HTML][HTML] SNP rs2057482 in HIF1A gene predicts clinical outcome of aggressive hepatocellular carcinoma patients after surgery

X Guo, D Li, Y Chen, J An, K Wang, Z Xu, Z Chen… - Scientific reports, 2015 - nature.com
Hypoxia-inducible factor 1α (HIF-1α) plays an important role in tumor growth and metastasis.
Genetic variations of HIF1A gene have been shown to influence the developing risk and …

[HTML][HTML] Association between HIF-1α C1772T/G1790A polymorphisms and cancer susceptibility: an updated systematic review and meta-analysis based on 40 case …

Q Yan, P Chen, S Wang, N Liu, P Zhao, A Gu - BMC cancer, 2014 - Springer
Abstract Background HIF-1 (hypoxia-inducible factor 1) is a transcriptional activator that
functions as a critical regulator of oxygen homeostasis. Recently, a large number of …

[HTML][HTML] Hypoxia-inducible factor-1α gene polymorphisms and cancer risk: a meta-analysis

T Zhao, J Lv, J Zhao, M Nzekebaloudou - Journal of Experimental & …, 2009 - Springer
Background The results from the published studies on the association between hypoxia-
inducible factor-1α (HIF-1α) polymorphisms and cancer risk are conflicting. In this meta …

[HTML][HTML] A meta-analysis of hypoxia inducible factor 1-alpha (HIF1A) gene polymorphisms: association with cancers

MT Anam, A Ishika, MB Hossain, Jesmin - Biomarker research, 2015 - Springer
Background Hypoxia inducible factor 1-alpha (HIF1A) is a transcription factor that plays
important role in regulating cascade of reactions. In this study, the effect of rs11549465 …

[PDF][PDF] HIF1A gene Pro582Ser polymorphism and susceptibility to digestive tract cancers: a meta-analysis of case-control studies

J Xu, L Xu, LT Li, Q You, LS Cha - Genet Mol Res, 2014 - m.jstshuichan.com
Many existing studies have demonstrated that common polymorphisms in the hypoxia
inducible factor-1α (HIF-1A) may contribute to the development of digestive tract cancers, but …

[HTML][HTML] HIF-1α rs11549465 C> T polymorphism contributes to increased cancer susceptibility: Evidence from 49 studies

HN Li, T He, YJ Zha, F Du, J Liu, HR Lin… - Journal of …, 2019 - ncbi.nlm.nih.gov
Abstract HIF-1α (hypoxia-inducible factor-1α) is a transcriptional factor that participates in the
regulation of oxygen homeostasis. Despites numbers of case-control studies working on this …

Polymorphisms in the hypoxia-inducible factor-1α gene confer susceptibility to pancreatic cancer

X Wang, Y Liu, H Ren, Z Yuan, S Li, J Sheng… - Cancer biology & …, 2011 - Taylor & Francis
The transcription factor hypoxia-inducible factor-1 (HIF-1) has α and β subunits. Recent
studies have shown that the HIF-1α gene may have C1772T and G1790A single nucleotide …