Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines

L Chen, H Qin, R Zhao, X Zhao, L Lin, Y Chen… - Science translational …, 2021 - science.org
Cancer vaccines based on resected tumors from patients have gained great interest as an
individualized cancer treatment strategy. However, eliciting a robust therapeutic effect with …

[HTML][HTML] Bacterial outer membrane vesicle-based cancer nanovaccines

X Gao, Q Feng, J Wang, X Zhao - Cancer Biology & Medicine, 2022 - ncbi.nlm.nih.gov
Tumor vaccines, a type of personalized tumor immunotherapy, have developed rapidly in
recent decades. These vaccines evoke tumor antigen-specific T cells to achieve immune …

Nanovaccines integrating endogenous antigens and pathogenic adjuvants elicit potent antitumor immunity

M Li, H Zhou, W Jiang, C Yang, H Miao, Y Wang - Nano Today, 2020 - Elsevier
Cancer nanovaccines have the ability to train the immune system to specifically recognize
and eliminate tumor cells. However, the vaccine's efficacy is hampered by limited access to …

[HTML][HTML] Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells

WL Liu, MZ Zou, T Liu, JY Zeng, X Li, WY Yu… - Nature …, 2019 - nature.com
Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using
exogenous antigens and adoptive cells, we show a concept of utilizing biologically …

Bifunctional fusion membrane‐based hydrogel enhances antitumor potency of autologous cancer vaccines by activating dendritic cells

Y Ke, J Zhu, Y Chu, L Cen, Y Fu, X Fan… - Advanced Functional …, 2022 - Wiley Online Library
Autologous tumor cell vaccine is an individualized tumor treatment strategy to elicit tumor‐
specific immune responses. However, it is difficult to exert efficacy in “cold” tumors, which …

[HTML][HTML] Nanocarriers based on bacterial membrane materials for cancer vaccine delivery

X Zhao, R Zhao, G Nie - Nature protocols, 2022 - nature.com
Here we present a protocol for the construction and use of two types of nanocarrier based on
bacterial membrane materials for cancer vaccine delivery. Cancer vaccines induce tumor …

[HTML][HTML] Engineered tumor cell-derived vaccines against cancer: The art of combating poison with poison

X Zhang, H Cui, W Zhang, Z Li, J Gao - Bioactive Materials, 2023 - Elsevier
Tumor vaccination is a promising approach for tumor immunotherapy because it presents
high specificity and few side effects. However, tumor vaccines that contain only a single …

PEGylated tumor cell membrane vesicles as a new vaccine platform for cancer immunotherapy

LJ Ochyl, JD Bazzill, C Park, Y Xu, R Kuai, JJ Moon - Biomaterials, 2018 - Elsevier
Despite the promise and advantages of autologous cancer cell vaccination, it remains
challenging to induce potent anti-tumor immune responses with traditional immunization …

Development of an in situ cancer vaccine via combinational radiation and bacterial‐membrane‐coated nanoparticles

RB Patel, M Ye, PM Carlson, A Jaquish… - Advanced …, 2019 - Wiley Online Library
Neoantigens induced by random mutations and specific to an individual's cancer are the
most important tumor antigens recognized by T cells. Among immunologically “cold” tumors …

Tumor associated macrophage and microbe: The potential targets of tumor vaccine delivery

J Jiang, J Mei, S Yi, C Feng, Y Ma, Y Liu, Y Liu… - Advanced drug delivery …, 2022 - Elsevier
The occurrence and development of tumors depend on the tumor microenvironment (TME),
which is made of various immune cells, activated fibroblasts, basement membrane …