Peripheral inflammatory biomarkers are associated with cognitive function and dementia: Framingham Heart Study Offspring cohort

J Chen, MF Doyle, Y Fang, J Mez, PK Crane… - Aging cell, 2023 - Wiley Online Library
Inflammatory protein biomarkers induced by immune responses have been associated with
cognitive decline and the pathogenesis of Alzheimer's disease (AD). Here, we investigate …

[HTML][HTML] Association between inflammatory biomarkers and cognitive aging

Y Fang, MF Doyle, J Chen, ML Alosco, J Mez… - PLoS …, 2022 - journals.plos.org
Inflammatory cytokines and chemokines related to the innate and adaptive immune system
have been linked to neuroinflammation in Alzheimer's Disease, dementia, and cognitive …

[HTML][HTML] Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study

K Trares, M Bhardwaj, L Perna, H Stocker… - Alzheimer's Research & …, 2022 - Springer
Background Chronic inflammation is a central feature of several forms of dementia.
However, few details on the associations of blood-based inflammation-related proteins with …

[HTML][HTML] Association between an inflammatory biomarker score and future dementia diagnosis in the population-based UK Biobank cohort of 500,000 people

K Mekli, A Lophatananon, A Maharani, JY Nazroo… - PloS one, 2023 - journals.plos.org
This study was designed to investigate the relationship between a systematic inflammatory
biomarker measure, concurrent and later cognitive performance, and future dementia risk …

Alzheimer's disease and inflammatory biomarkers positively correlate in plasma in the UK‐ADRC cohort

KE Foley, Z Winder, TL Sudduth, BJ Martin… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Protein‐based plasma assays provide hope for improving accessibility and
specificity of molecular diagnostics to diagnose dementia. METHODS Plasma was obtained …

Peripheral inflammatory biomarkers predict the deposition and progression of amyloid-β in cognitively unimpaired older adults

LE Oberlin, KI Erickson, R Mackey, WE Klunk… - Brain, behavior, and …, 2021 - Elsevier
Introduction Systemic inflammation has been increasingly implicated in the pathogenesis of
Alzheimer's disease (AD), yet the mechanistic and temporal specificity of this relationship is …

[HTML][HTML] Associations of circulating C-reactive proteins, APOE ε4, and brain markers for Alzheimer's disease in healthy samples across the lifespan

Y Wang, H Grydeland, JM Roe, M Pan… - Brain, Behavior, and …, 2022 - Elsevier
The apolipoprotein E gene ε4 allele (APOE ε4) and higher circulating level of C-reactive
protein (CRP) have been extensively investigated as risk factors for Alzheimer's disease …

[HTML][HTML] Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype

JS Friedberg, N Aytan, JD Cherry, W Xia… - Scientific reports, 2020 - nature.com
Alzheimer disease (AD) is a chronic neurodegenerative disease with a multitude of
contributing genetic factors, many of which are related to inflammation. The apolipoprotein E …

[HTML][HTML] Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

D Felsky, E Patrick, JA Schneider, S Mostafavi… - Molecular …, 2018 - Springer
Background The role of the innate immune system in Alzheimer's disease (AD) and
neurodegenerative disease susceptibility has recently been highlighted in genetic studies …

[HTML][HTML] Plasma proteins related to inflammatory diet predict future cognitive impairment

MR Duggan, L Butler, Z Peng, GN Daya… - Molecular …, 2023 - nature.com
Dysregulation of the immune system and dietary patterns that increase inflammation can
increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional …