The gastrointestinal tract maintains energy and glucose homeostasis, in part through
nutrient-sensing and subsequent signaling to the brain and other tissues. In this review, we …

In type 2 diabetes and obesity, the homeostatic control of glucose and energy balance is
impaired, leading to hyperglycemia and hyperphagia. Recent studies indicate that nutrient …

The gastrointestinal tract plays a role in the development and treatment of metabolic
diseases. During a meal, the gut provides crucial information to the brain regarding …

The gastrointestinal (GI) tract is a highly specialized sensory organ that provides crucial
negative feedback during a meal, partly via a gut–brain axis. More specifically …

Despite significant progress in understanding the homeostatic regulation of energy balance,
successful therapeutic options for curbing obesity remain elusive. One potential target for the …

The enteroendocrine system is the primary sensor of ingested nutrients and is responsible
for secreting an array of gut hormones, which modulate multiple physiological responses …

The release of gut hormones involved in the control of food intake is dependent on the acute
nutritional status of the body, suggesting that chemosensory mechanisms are involved in the …

The gastrointestinal tract, the key interface between ingested nutrients and the body, plays a
critical role in regulating energy homeostasis. Gut-derived signals convey information …

Because human energy metabolism evolved to favor adiposity over leanness, the
availability of palatable, easily attainable, and calorically dense foods has led to …

The gut is anatomically positioned to play a critical role in the regulation of metabolic
homeostasis, providing negative feedback via nutrient sensing and local hormonal …