[HTML][HTML] TFE3-mediated impairment of lysosomal biogenesis and defective autophagy contribute to fluoride-induced hepatotoxicity

Z Hu, W Xu, J Zhang, Y Tang, H Xing, P Xu… - Ecotoxicology and …, 2023 - Elsevier
Excessive fluoride exposure can cause liver injury, but the specific mechanisms need further
investigation. We aimed to explore the role of impaired lysosomal biogenesis and defective …

[HTML][HTML] Cross-talk between autophagy and ferroptosis contributes to the liver injury induced by fluoride via the mtROS-dependent pathway

W Xu, Z Hu, J Zhang, Y Tang, H Xing, P Xu… - Ecotoxicology and …, 2023 - Elsevier
Fluoride can induce hepatotoxicity, but the mechanisms responsible are yet to be
investigated. This study sought to investigate the role and mechanism of mitochondrial …

Fluoride exposure confers NRF2 activation in hepatocyte through both canonical and non‐canonical signaling pathways

M Li, Y Wang, R Liu, M Shi, Y Zhao… - Environmental …, 2024 - Wiley Online Library
Due to the high abundance in the Earth's crust and industrial application, fluoride is widely
present in our living environment. However, excessive fluoride exposure causes toxicity in …

Fluoride induces apoptosis and autophagy through the IL-17 signaling pathway in mice hepatocytes

Y Zhao, Y Li, J Wang, RK Manthari, J Wang - Archives of toxicology, 2018 - Springer
Previous studies have reported that excessive fluoride exposure induced liver damage.
However, the underlying mechanism of fluoride-induced hepatic toxicity is still unclear …

Novel pathways of fluoride-induced hepatotoxicity: P53-dependent ferroptosis induced by the SIRT1/FOXOs pathway and Nrf2/HO-1 pathway

D Wang, K Yin, Y Zhang, H Lu, L Hou, H Zhao… - … and Physiology Part C …, 2023 - Elsevier
Fluoride (F) is an environmental pollutant that continues to threaten human health. Long-
term or excessive fluoride exposure can cause a series of acute or chronic systemic and …

Fluoride exposure induces mitochondrial damage and mitophagy via activation of the IL-17A pathway in hepatocytes

Y Zhao, J Wang, J Zhang, Z Sun, R Niu… - Science of the Total …, 2022 - Elsevier
As an environmental toxicant, the damage of fluoride to the body has attracted global
attention. Because liver is an essential organ for fluoride accumulation and damage. Our …

Mitochondrial respiratory chain damage and mitochondrial fusion disorder are involved in liver dysfunction of fluoride-induced mice

H Wang, J Liu, S Wei, W Zhao, S Zhu, B Zhou - Chemosphere, 2020 - Elsevier
Our previous study showed that excessive fluoride (F) intake can induce liver dysfunction.
The aim of this study was to investigate the mechanisms of F-induced mitochondrial damage …

Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity

Q Niu, J Chen, T Xia, P Li, G Zhou, C Xu, Q Zhao… - Environmental …, 2018 - Elsevier
Fluoride is capable of inducing neurotoxicity, but its mechanisms remain elusive. This study
aimed to explore the roles of endoplasmic reticulum (ER) stress and autophagy in sodium …

[Retracted] Fluoride Exposure Suppresses Proliferation and Enhances Endoplasmic Reticulum Stress and Apoptosis Pathways in Hepatocytes by Downregulating …

Y Yu, L Li, W Yu, Z Guan - BioMed Research International, 2022 - Wiley Online Library
Objective. To explore the function and mechanism of Sirt‐1 in fluorine‐induced liver injury.
Method. Fluorosis rats were first established. The fluorine content, pathological structure …

Excessive Lysosomal Stress Response and Consequently Impaired Autophagy Contribute to Fluoride-Induced Developmental Neurotoxicity

W Xu, Z Hu, Y Tang, J Zhang, S Xu, Q Niu - Biological Trace Element …, 2023 - Springer
Fluoride can cause developmental neurotoxicity; however, the precise mechanism has yet to
be determined. We aimed to explore the possible role and mechanism of fluoride-induced …