Acute promyelocytic leukemia (APL) is characterized by the presence of rearrangements
involving the retinoic acid receptor α (RARα) gene and a variable incidence in different …

The PML/RARα fusion gene in acute promyelocytic leukaemia (APL) has three subtypes
based on the breakpoint site of the PML gene: long (bcr1), short (bcr3) and variable (bcr2) …

Acute promyelocytic leukemia (APL) accounts for approximately 15% of all cases of acute
myeloid leukemia (AML). Patients with APL have the characteristic chromosome …

Once the diagnostic suspicion of acute promyelocytic leukemia (APL) has been raised,
international guidelines recommend prompt initiation of tailored therapy and supportive …

In each case of acute promyelocytic leukemia (APL) one of three PML-RARα mRNA types is
produced, depending on the break/fusion site in the PML gene that is linked to a common …

Acute promyelocytic leukemia is characterized the PML/RARa chimeric fusion gene,
transcript and protein; the breakpoint cluster regions (bcr) in the PML gene may occur in 3 …

Acute promyelocytic leukemia (APL) is a good model for studying the human malignancies
in that up to 90% of APL patients can achieve complete remission (CR) with a differentiation …

Abstract The t (15; 17) translocation is specifically observed in patients with promyelocytic
leukemia (AML3). The chromosomal rearrangement juxtaposes the retinoic acid receptor …

Background The availability of genotype‐specific therapy for PML/RARαpos acute
promyelocytic leukemia (APL) requires that this disease be precisely diagnosed …

Acute promyelocytic leukemia (APL) is characterized by a specific t (15; 17) translocation
and a high rate of response to all-trans retinoic acid. The translocation generates a …