p53-induced GDF-15 expression promotes a pro-regenerative response in human chondrocytes upon cartilage injury
SS Marques, A Liebaug, S Maurer, D Rothenbacher… - bioRxiv, 2024 - biorxiv.org
Posttraumatic osteoarthritis (PTOA) is a special form of OA, developing after joint injuries.
Except for some minor differences between the clinical characteristics of patients suffering …
Except for some minor differences between the clinical characteristics of patients suffering …
[HTML][HTML] Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis
K Kania, F Colella, AHK Riemen, H Wang… - Scientific Reports, 2020 - nature.com
Abstract Growth and Differentiation Factor 5 (GDF5) is a key risk locus for osteoarthritis (OA).
However, little is known regarding regulation of Gdf5 expression following joint tissue …
However, little is known regarding regulation of Gdf5 expression following joint tissue …
GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury
Musculoskeletal disorders contribute substantially to worldwide disability. Anterior cruciate
ligament (ACL) tears result in unresolved muscle weakness and posttraumatic osteoarthritis …
ligament (ACL) tears result in unresolved muscle weakness and posttraumatic osteoarthritis …
[HTML][HTML] Intra-articular supplementation with recombinant human GDF5 arrests disease progression and stimulates cartilage regeneration in the rat medial meniscus …
BA Byers, WR Parrish, J Geesin… - Osteoarthritis and …, 2014 - oarsijournal.com
Purpose: Genome-wide association studies and investigation of osteoarthritis (OA) risk
alleles suggest that reduced levels of functional Growth and Differentiation Factor 5 (GDF5) …
alleles suggest that reduced levels of functional Growth and Differentiation Factor 5 (GDF5) …
[HTML][HTML] Role of GDF15/MAPK14 axis in chondrocyte senescence as a novel senomorphic agent in osteoarthritis
PW Weng, NW Pikatan, SA Setiawan… - International journal of …, 2022 - mdpi.com
Osteoarthritis (OA) is most prevalent in older individuals and exerts a heavy social and
economic burden. However, an effective and noninvasive approach to OA treatment is …
economic burden. However, an effective and noninvasive approach to OA treatment is …
Growth differentiation factor 5 in cartilage and osteoarthritis: a possible therapeutic candidate
K Sun, J Guo, X Yao, Z Guo, F Guo - Cell Proliferation, 2021 - Wiley Online Library
Abstract Growth differentiation factor 5 (GDF‐5) is essential for cartilage development and
homeostasis. The expression and function of GDF‐5 are highly associated with the …
homeostasis. The expression and function of GDF‐5 are highly associated with the …
Modulatory effects of inflammation and therapy on GDF‐5 expression in rheumatoid arthritis synovium
CP Bramlage, C Kaps, U Ungethüm… - Scandinavian journal …, 2008 - Taylor & Francis
Objective: Growth differentiation factor‐5 (GDF‐5), a member of the transforming growth
factor (TGF)‐β family, is involved in joint development during embryogenesis and has the …
factor (TGF)‐β family, is involved in joint development during embryogenesis and has the …
GDF-5 is suppressed by IL-1β and enhances TGF-β3-mediated chondrogenic differentiation in human rheumatoid fibroblast-like synoviocytes
FL Liu, LH Lin, HK Sytwu, DM Chang - Experimental and molecular …, 2010 - Elsevier
OBJECTIVE: To investigate the expression of growth differentiation factor-5 (GDF-5) in
chondrocytes (HC) and fibroblast-like synoviocytes (FLS) from humans with rheumatoid …
chondrocytes (HC) and fibroblast-like synoviocytes (FLS) from humans with rheumatoid …
[HTML][HTML] Expression of growth and differentiation factor 5 during joint repair and osteoarthritis
K Kania, F Colella, AH Riemen, H Wang… - Osteoarthritis and …, 2020 - oarsijournal.com
Purpose: Growth and differentiation factor 5 (GDF5) is a key risk locus for osteoarthritis (OA),
with single-nucleotide polymorphisms that result in decreased GDF5 expression contributing …
with single-nucleotide polymorphisms that result in decreased GDF5 expression contributing …
GDF5 modifies disease in OA rat model
J McHugh - Nature Reviews Rheumatology, 2017 - nature.com
Growth and differentiation factor 5 (GDF5) could halt and reverse osteoarthritis (OA)
progression, according to a new study published in Osteoarthritis and Cartilage …
progression, according to a new study published in Osteoarthritis and Cartilage …