Cardiogenesis within embryos or associated with heart repair requires stem cell
differentiation into energetically competent, contracting cardiomyocytes. While it is widely …

Alterations in energy metabolism play a major role in the lineage of cardiomyocytes, such as
the dramatic changes that occur in the transition from neonate to newborn. As …

Decoding of the bioenergetic signature underlying embryonic stem cell cardiac
differentiation has revealed a mandatory transformation of the metabolic infrastructure with …

genes and transcription factors, and promoting stem cell cardiac differentiation. 20–22 Such
cardiogenic effects appear to be concentration-dependent, as high levels of ROS can delay …

Heart failure is a major cause of morbidity and mortality in the world. Cardiac energy
metabolism, specifically fatty acid and glucose metabolism, is altered in heart failure and has …

Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs)
inadequately recapitulate complete development and result in PSC-derived cardiomyocytes …

Heart failure is the leading cause of death worldwide. The inability of the adult mammalian
heart to regenerate following injury results in the development of systolic heart failure. Thus …

The ultrastructure of the cardiac myocyte is remarkable for the high density of mitochondria
tightly packed between sarcomeres. This structural organization is designed to provide …

The heart must function continuously as it is responsible for both supplying oxygen and
nutrients throughout the entire body, as well as for the transport of waste products to …

During hypertrophy, proliferation of mitochondria does not keep pace with the increasing
energy demand of the heart. This probably contributes importantly to cardiac failure, together …