T cells respond to threats in an antigen-specific manner using T cell receptors (TCRs) that
recognize short peptide antigens presented on major histocompatibility complex (MHC) …

T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …

In order to survey a universe of major histocompatibility complex (MHC)-presented peptide
antigens whose numbers greatly exceed the diversity of the T cell repertoire, T cell receptors …

Adaptive immune responses often begin with the formation of a molecular complex between
a T-cell receptor (TCR) and a peptide antigen bound to a major histocompatibility complex …

The promiscuous nature of T-cell receptors (TCRs) allows T cells to recognize a large variety
of pathogens, but makes it challenging to understand and control T-cell recognition. Existing …

Adaptive immunity is based on peptide antigen recognition. Our ability to harness the
immune system for therapeutic gain relies on the discovery of the T cell receptor (TCR) …

Abstract αβ T cell antigen receptors (TCRs) bind complexes of peptide and major
histocompatibility complex (pMHC) with low affinity, which poses a considerable challenge …

T cell recognition of specific antigens mediates protection from pathogens and controls
neoplasias, but can also cause autoimmunity. Our knowledge of T cell antigens and their …

AT cell mounts an immune response by measuring the binding strength of its T cell receptor
(TCR) for peptide-loaded MHCs (pMHC) on an antigen-presenting cell. How T cells convert …

Although critical to T cell function, antigen specificity is often omitted in high-throughput
multiomics-based T cell profiling due to technical challenges. We describe a high …