Aims Prostate cancer is the second most frequently malignancy in men worldwide. Most
deaths are caused by metastasis, and tumor cell dissemination involves the interaction with …

Background: Our previous study demonstrated that extracellular adenosine 5′-triphosphate
(ATP) stimulated prostate cancer cell invasion via P2Y receptors. However, the purinergic …

As one member of G protein-coupled P2Y receptors, P2Y2 receptor can be equally activated
by extracellular ATP and UTP. Our previous studies have proved that activation of P2Y2 …

Epidemiological studies indicate that statins, cholesterol-lowering drugs, prevent aggressive
prostate cancer and other types of cancer. Employing essentially non-prostate cell lines, we …

The G protein-coupled P2Y purinoceptors have wide physiological functions, but their role
(s) in tumor progression remain unclear. Here, we report that stimulation of P2Y receptors …

Although the potential roles of endothelial cells in the microvascules of prostate cancer
during angiogenesis have been documented, their direct impacts on the prostate cancer …

P2 purinoceptors are composed of ligand-gated ion channel type (P2X receptor) and G
protein-coupled metabolite type (P2Y receptor). Both these receptors have played important …

Extracellular ATP mediates a wide range of physiological effects, including cell proliferation,
differentiation, maturation, and migration. However, the effect of ATP on cell proliferation has …

Objective To explore whether ERK1/2 and p38 pathways mediate P2Y receptor-induced
prostate cancer invasion. Methods The two subclones from the PC-3 human prostate …

Tumor metastasis is considered the main cause of mortality in cancer patients, thus it is
important to investigate the differences between high-and low-metastatic cancer cells. Our …