Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens

AM Naleid, MK Grace, DE Cummings, AS Levine - Peptides, 2005 - Elsevier
Ghrelin, a powerful orexigenic peptide released from the gut, stimulates feeding when
injected centrally and has thus far been implicated in regulation of metabolic, rather than …

Ghrelin directly targets the ventral tegmental area to increase food motivation

KP Skibicka, C Hansson, M Alvarez-Crespo, PA Friberg… - Neuroscience, 2011 - Elsevier
Ghrelin, a circulating orexigenic stomach-derived hormone, has recently been implicated in
extra-homeostatic feeding, increasing food reward and food-motivated behavior. The …

Ghrelin signalling on food reward: a salient link between the gut and the mesolimbic system

M Perello, SL Dickson - Journal of neuroendocrinology, 2015 - Wiley Online Library
'Hunger is the best spice'is an old and wise saying that acknowledges the fact that almost
any food tastes better when we are hungry. The neurobiological underpinnings of this lore …

PRECLINICAL STUDY: FULL ARTICLE: Ghrelin increases intake of rewarding food in rodents

E Egecioglu, E Jerlhag, N Salomé… - Addiction …, 2010 - Wiley Online Library
We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key
node in the mesolimbic reward system, is important for the rewarding and motivational …

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

A Abizaid, ZW Liu, ZB Andrews… - The Journal of …, 2006 - Am Soc Clin Investig
The gut hormone ghrelin targets the brain to promote food intake and adiposity. The ghrelin
receptor growth hormone secretagogue 1 receptor (GHSR) is present in hypothalamic …

PRECLINICAL STUDY: Ghrelin stimulates locomotor activity and accumbal dopamine‐overflow via central cholinergic systems in mice: implications for its involvement …

E Jerlhag, E Egecioglu, SL Dickson… - Addiction …, 2006 - Wiley Online Library
It is becoming increasingly apparent that there is a degree of neurochemical overlap
between the reward systems and those regulating energy balance. We therefore …

Concomitant release of ventral tegmental acetylcholine and accumbal dopamine by ghrelin in rats

E Jerlhag, AC Janson, S Waters, JA Engel - PloS one, 2012 - journals.plos.org
Ghrelin, an orexigenic peptide, regulates energy balance specifically via hypothalamic
circuits. Growing evidence suggest that ghrelin increases the incentive value of motivated …

Ghrelin and dopamine: new insights on the peripheral regulation of appetite

A Abizaid - Journal of neuroendocrinology, 2009 - Wiley Online Library
A review is provided of current evidence supporting the actions of the stomach‐derived
peptide ghrelin on ventral tegmental area (VTA) dopamine cells to increase food intake and …

Preclinical study: ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus …

E Jerlhag, E Egecioglu, SL Dickson… - Addiction …, 2007 - Wiley Online Library
Ghrelin stimulates appetite, increases food intake and causes adiposity by mechanisms that
include direct actions on the brain. Previously, we showed that intracerebroventricular …

Systemic administration of ghrelin increases extracellular dopamine in the shell but not the core subdivision of the nucleus accumbens

D Quarta, C Di Francesco, S Melotto… - Neurochemistry …, 2009 - Elsevier
The gut-hormone ghrelin endogenously binds to the ghrelin receptor (GHS-R) to promote
foraging and feeding behaviours mainly via the hypothalamic arcuate nucleus (ARC). GHS …