Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis
SN Stacey, F Zink, GH Halldorsson, L Stefansdottir… - Nature Genetics, 2023 - nature.com
Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis
SP Kar, PM Quiros, M Gu, T Jiang, J Mitchell… - Nature Genetics, 2022 - nature.com
Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven
by somatic driver mutations, affects over a third of people, yet remains poorly understood …
by somatic driver mutations, affects over a third of people, yet remains poorly understood …
Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis
R Saiki, Y Momozawa, Y Nannya, MM Nakagawa… - Nature medicine, 2021 - nature.com
Clonal hematopoiesis (CH) in apparently healthy individuals is implicated in the
development of hematological malignancies (HM) and cardiovascular diseases. Previous …
development of hematological malignancies (HM) and cardiovascular diseases. Previous …
Prevalence, predictors, and outcomes of clonal hematopoiesis in individuals aged≥ 80 years
IA van Zeventer, JB Salzbrunn, AO de Graaf… - Blood …, 2021 - ashpublications.org
Clonal hematopoiesis (CH), characterized by a fraction of peripheral blood cells carrying an
acquired genetic variant, emerges with age. Although in general CH is associated with …
acquired genetic variant, emerges with age. Although in general CH is associated with …
Distinction of lymphoid and myeloid clonal hematopoiesis
Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal
expansion of blood cells. Somatic gene mutations associated with hematologic …
expansion of blood cells. Somatic gene mutations associated with hematologic …
Inherited causes of clonal haematopoiesis in 97,691 whole genomes
Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown. The age-related acquisition of …
through which ageing confers this risk are largely unknown. The age-related acquisition of …
Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
F Zink, SN Stacey, GL Norddahl… - Blood, The Journal …, 2017 - ashpublications.org
Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single dominant hematopoietic stem cell lineage. Somatic mutations in …
derived from a single dominant hematopoietic stem cell lineage. Somatic mutations in …
Germline risk of clonal haematopoiesis
Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …
somatic mutations that is associated with an increased risk of haematological malignancies …
Monogenic and polygenic inheritance become instruments for clonal selection
Clonally expanded blood cells that contain somatic mutations (clonal haematopoiesis) are
commonly acquired with age and increase the risk of blood cancer,,,,,,,–. The blood clones …
commonly acquired with age and increase the risk of blood cancer,,,,,,,–. The blood clones …
Common and rare variant associations with clonal haematopoiesis phenotypes
MD Kessler, A Damask, S O'Keeffe, N Banerjee, D Li… - Nature, 2022 - nature.com
Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been
associated with ageing and adverse health outcomes,,,–. Here we use exome sequence …
associated with ageing and adverse health outcomes,,,–. Here we use exome sequence …