[HTML][HTML] CSNK2 in cancer: pathophysiology and translational applications
SW Strum, L Gyenis, DW Litchfield - British journal of cancer, 2022 - nature.com
Abstract Protein kinase CSNK2 (CK2) is a pleiotropic serine/threonine kinase frequently
dysregulated in solid and hematologic malignancies. To consolidate a wide range of …
dysregulated in solid and hematologic malignancies. To consolidate a wide range of …
Molecular pathways: emergence of protein kinase CK2 (CSNK2) as a potential target to inhibit survival and DNA damage response and repair pathways in cancer …
AJ Rabalski, L Gyenis, DW Litchfield - Clinical Cancer Research, 2016 - AACR
Protein kinase CK2 (designated CSNK2) is a constitutively active protein kinase with a vast
repertoire of putative substrates that has been implicated in several human cancers …
repertoire of putative substrates that has been implicated in several human cancers …
[HTML][HTML] Prognostic value and immunological role of CSNK1D in human cancers
J Wang, B Hu, W Wang - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
CSNK1D, also known as CK1δ, is a crucial gene involved in various biological processes
such as cell cycle, transcriptional regulation, apoptosis, cell polarity, and cell motility. It is …
such as cell cycle, transcriptional regulation, apoptosis, cell polarity, and cell motility. It is …
Emergence of protein kinase CK2 as a key target in cancer therapy
JH Trembley, Z Chen, G Unger, J Slaton, BT Kren… - Biofactors, 2010 - Wiley Online Library
Protein kinase CK2, a protein serine/threonine kinase, plays a global role in activities related
to cell growth, cell death, and cell survival. CK2 has a large number of potential substrates …
to cell growth, cell death, and cell survival. CK2 has a large number of potential substrates …
Inhibition of protein kinase CK2 expression and activity blocks tumor cell growth
D Zhu, J Hensel, R Hilgraf, M Abbasian… - Molecular and cellular …, 2010 - Springer
Abstract Protein kinase CK2 (CK2) is a highly conserved and ubiquitous serine/threonine
kinase. It is a multifunctional and pleiotropic protein kinase implicated in the regulation of …
kinase. It is a multifunctional and pleiotropic protein kinase implicated in the regulation of …
[HTML][HTML] SGK1 in human cancer: emerging roles and mechanisms
Y Sang, P Kong, S Zhang, L Zhang, Y Cao… - Frontiers in …, 2021 - frontiersin.org
Serum and glucocorticoid-induced protein kinase 1 (SGK1) is a member of the “AGC”
subfamily of protein kinases, which shares structural and functional similarities with the AKT …
subfamily of protein kinases, which shares structural and functional similarities with the AKT …
Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2
JS Duncan, DW Litchfield - Biochimica et Biophysica Acta (BBA)-Proteins …, 2008 - Elsevier
CK2 is a highly conserved protein serine/threonine kinase that is ubiquitously distributed in
eukaryotes, constitutively active and has been implicated in multiple cellular functions, as …
eukaryotes, constitutively active and has been implicated in multiple cellular functions, as …
[HTML][HTML] Chemical genetic validation of CSNK2 substrates using an inhibitor-resistant mutant in combination with triple SILAC quantitative phosphoproteomics
L Gyenis, D Menyhart, ES Cruise, K Jurcic… - Frontiers in Molecular …, 2022 - frontiersin.org
Casein Kinase 2 (CSNK2) is an extremely pleiotropic, ubiquitously expressed protein kinase
involved in the regulation of numerous key biological processes. Mapping the CSNK2 …
involved in the regulation of numerous key biological processes. Mapping the CSNK2 …
Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma
Purpose: Gliomas are the most frequently occurring primary malignancies in the brain, and
glioblastoma is the most aggressive of these tumors. Protein kinase CK2 is composed of two …
glioblastoma is the most aggressive of these tumors. Protein kinase CK2 is composed of two …
[HTML][HTML] SGK3 (CISK) may induce tumor angiogenesis (Hypothesis)
M Hou, Y Lai, S He, W He, H Shen… - Oncology …, 2015 - spandidos-publications.com
Serum-and glucocorticoid-inducible protein kinase 3 (SGK3), also known as cytokine-
independent survival kinase (CISK), encoded by chromosome 8q12. 2, is a downstream …
independent survival kinase (CISK), encoded by chromosome 8q12. 2, is a downstream …