The brain's high bioenergetic state is paralleled by high metabolic waste production.
Authentic lymphatic vasculature is lacking in brain parenchyma. Cerebrospinal fluid (CSF) …

Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …

The central nervous system (CNS) is unique in being the only organ system lacking
lymphatic vessels to assist in the removal of interstitial metabolic waste products. Recent …

The glymphatic system is responsible for the clearance of the potentially harmful metabolic
waste of the central nervous system. The prevalent theory is that the cerebrospinal fluid …

The cerebral vasculature serves as the crossroads of the CNS, supporting exchange of
nutrients, metabolic wastes, solutes and cells between the compartments of the brain …

The complex and dynamic system of fluid flow through the perivascular and interstitial
spaces of the CNS has new-found implications for neurological diseases. CSF movement …

The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the
endfeet of astrocytes, which can deliver nutrients and active substances to the brain …

The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in
recent years, highlighted that fluid is directionally transported within the central nervous …

The glymphatic system is a glial-dependent waste clearance pathway in the brain, in place
of lymphatic vessels, dedicated to drain away soluble waste proteins and metabolic …

The newly discovered glymphatic system acts as pseudolymphatic vessels subserving brain
waste clearance and is functionally dependent on astrocytic aquaporin‐4 channels. The …