[HTML][HTML] Anti-LL37 antibodies are present in psoriatic arthritis (PsA) patients: new biomarkers in PsA

L Frasca, R Palazzo, MS Chimenti, S Alivernini… - Frontiers in …, 2018 - frontiersin.org
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis. A third of
psoriatic patients develop PsA via unknown mechanisms. No reliable diagnostic markers …

[HTML][HTML] Native/citrullinated LL37-specific T-cells help autoantibody production in Systemic Lupus Erythematosus

R Lande, R Palazzo, N Gestermann, C Jandus… - Scientific reports, 2020 - nature.com
LL37 exerts a dual pathogenic role in psoriasis. Bound to self-DNA/RNA, LL37 licenses
autoreactivity by stimulating plasmacytoid dendritic cells-(pDCs)-Type I interferon (IFN-I) and …

Identification of novel autoantibodies associated with psoriatic arthritis

Y Yuan, J Qiu, ZT Lin, W Li, C Haley… - Arthritis & …, 2019 - Wiley Online Library
Objective The autoimmune etiology in psoriasis remains to be clarified. We therefore
undertook this study to identify novel pathogenic autoantigens and autoantibodies in …

[HTML][HTML] The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis

R Lande, E Botti, C Jandus, D Dojcinovic… - Nature …, 2014 - nature.com
Psoriasis is a common T-cell-mediated skin disease with 2–3% prevalence worldwide.
Psoriasis is considered to be an autoimmune disease, but the precise nature of the …

[HTML][HTML] Cathelicidin LL-37: A new important molecule in the pathophysiology of systemic lupus erythematosus

A Moreno-Angarita, CC Aragón, GJ Tobón - Journal of translational …, 2020 - Elsevier
Cathelicidin LL-37 is an antimicrobial peptide that is synthesized by epithelial cells,
neutrophils, or lymphocytes and act as an essential defense mechanism against bacterial …

Autoantigens ADAMTSL 5 and LL 37 are significantly upregulated in active Psoriasis and localized with keratinocytes, dendritic cells and other leukocytes

J Fuentes‐Duculan, KM Bonifacio… - Experimental …, 2017 - Wiley Online Library
Psoriasis is a common immune‐mediated disease that affects 2%‐4% of individuals in North
America and Europe. In the past decade, advances in research have led to an improved …

Current knowledge on autoantigens and autoantibodies in psoriasis

LL Ten Bergen, A Petrovic… - … Journal of Immunology, 2020 - Wiley Online Library
In the past decades, clinical and experimental evidence has demonstrated that psoriasis is
an immune‐mediated inflammatory disease of the skin that occurs in genetically susceptible …

The contribution of IL-17 to the development of autoimmunity in psoriasis

M Furue, T Kadono - Innate immunity, 2019 - journals.sagepub.com
Psoriasis is an (auto) immune-mediated disease that manifests as widespread
desquamative erythema. The TNF-α/IL-23/IL-17A axis is crucial to its pathogenesis, which is …

Arthritis in systemic lupus erythematosus is characterized by local IL-17A and IL-6 expression in synovial fluid

N Sippl, F Faustini, J Rönnelid… - Clinical & …, 2021 - academic.oup.com
Arthritis is a common clinical feature of systemic lupus erythematosus (SLE) and is usually
non-erosive, as opposed to rheumatoid arthritis (RA). While RA synovial pathology has been …

The Th17/IL‐23 axis and natural immunity in psoriatic arthritis

S Maeda, Y Hayami, T Naniwa… - International journal of …, 2012 - Wiley Online Library
Psoriatic arthritis (PsA) is a chronic inflammatory skin disease that causes enthesitis and
destructive arthritis and significantly lowers patient quality of life. Recognition of the two …