Steroids hormones possess two distinct actions, a delayed genomic effect and a rapid non-
genomic effect. Rapid steroid-triggered signaling is mediated by specific receptors localized …

Steroids play an important role in the regulation of normal physiology and the treatment of
disease. Steroid receptors have classically been described as ligand-activated transcription …

Estrogen is a critical steroid in human physiology exerting its effect both at the transcriptional
level as well as at the level of rapid intracellular signaling through second messengers …

The ability of a cell to respond to a particular hormone depends on the presence of specific
receptors for those hormones. Once the hormone has bound to its receptor, and following …

Sex steroid hormones, including estrogen, progesterone, and androgen, mediate their
biological effects on cell proliferation, differentiation, and homeostasis through their …

G protein-coupled receptors (GPCRs) are cell membrane receptors for various ligands.
Recent studies have suggested that GPCRs transmit animal steroid hormone signals …

Estrogen mediate its biological effects through its association with estrogen receptors (ERs).
They also regulate the expression of a variety of genes involved in distinct physiological …

The classical estrogen receptor (ER) mediates genomic as well as rapid nongenomic
estradiol responses. In case of genomic responses, the ER acts as a ligand-dependent …

Steroid hormones such as estrogens are known to signal through ligand-regulated
transcription factors of the nuclear receptor superfamily. In addition, they elicit rapid …

Steroid hormone receptors have been traditionally considered to act via the regulation of
transcriptional processes, involving nuclear translocation and binding to specific response …