The transparency of the cornea along with its dense sensory innervation and resident
leukocyte populations make it an ideal tissue to study interactions between the nervous and …

Corneal nerves are instrumental to maintain cornea integrity through regulation of key
physiological functions such as tear secretion, blink reflex, and neuropeptide turnover …

Ocular surface neuropeptides are vital molecules primarily involved in maintaining ocular
surface integrity and homeostasis. They also serve as communication channels between the …

Keratocytes, the quiescent cells of the corneal stroma, play a crucial role in corneal wound
healing. Neuropeptides and neurotransmitters are usually associated with neuronal …

Neuropeptides are known as important mediators between the nervous and immune
systems. Recently, the role of the corneal nerve in the pathogenesis of various ocular …

In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …

As already shown in other mucosal surfaces, neurogenic inflammation and innate immunity
may work together to protect the ocular surface. In this review, we present the most recent …

This review provides a comprehensive analysis of the structure, neurochemical content, and
functions of corneal nerves, with special emphasis on human corneal nerves. A revised …

Regional immunoregulatory mechanisms insure that the most effective immune defense
mounted is in proportion with preserving unique tissue functionalities. Immune-privileged …

In recent decades, the role of neuropeptides in physiology and pathology has been
elucidated. Various neuropeptides are expressed at the ocular surface, where they facilitate …