[HTML][HTML] Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity

SJ Lee, G Sanchez-Watts, JP Krieger, A Pignalosa… - Molecular …, 2018 - Elsevier
Abstract Objective Glucagon-like peptide-1 (GLP-1) neurons in the hindbrain densely
innervate the dorsomedial hypothalamus (DMH), a nucleus strongly implicated in body …

Glucagon-like peptide-1 regulates brown adipose tissue thermogenesis via the gut-brain axis in rats

JP Krieger, EP Santos da Conceição… - American Journal …, 2018 - journals.physiology.org
Endogenous intestinal glucagon-like peptide-1 (GLP-1) controls satiation and glucose
metabolism via vagal afferent neurons (VANs). Recently, VANs have received increasing …

Hypothalamic GLP-1: the control of BAT thermogenesis and browning of white fat

M López, C Diéguez, R Nogueiras - Adipocyte, 2015 - Taylor & Francis
Brown adipose tissue (BAT) is a specialized organ responsible for thermogenesis, a process
required for maintaining body temperature. Since the discovery that BAT and brite/beige …

Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling

SH Lockie, KM Heppner, N Chaudhary… - Diabetes, 2012 - Am Diabetes Assoc
We studied interscapular brown adipose tissue (iBAT) activity in wild-type (WT) and
glucagon-like peptide 1 receptor (GLP-1R)–deficient mice after the administration of the …

[HTML][HTML] Glucagon, GLP-1 and thermogenesis

I González-García, E Milbank, C Diéguez… - International journal of …, 2019 - mdpi.com
Brown adipose tissue (BAT) thermogenesis is a conserved mechanism to maintain body
temperature in mammals. However, since BAT contribution to energy expenditure can …

[HTML][HTML] Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism

JH Jeong, DK Lee, C Blouet, HH Ruiz, C Buettner… - Molecular …, 2015 - Elsevier
Objective Brown adipose tissue (BAT) thermogenesis is critical in maintaining body
temperature. The dorsomedial hypothalamus (DMH) integrates cutaneous thermosensory …

[HTML][HTML] Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis

A Guilherme, DJ Pedersen, F Henriques… - Molecular …, 2018 - Elsevier
Objective Crosstalk between adipocytes and local neurons may be an important regulatory
mechanism to control energy homeostasis. We previously reported that perturbation of …

[HTML][HTML] CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity

R Rodríguez-Rodríguez, C Miralpeix, A Fosch… - Molecular …, 2019 - Elsevier
Abstract Objective Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central
regulation of energy homeostasis. Our aim was to investigate whether CPT1C in the …

[HTML][HTML] Endogenous glucagon-like peptide-1 suppresses high-fat food intake by reducing synaptic drive onto mesolimbic dopamine neurons

XF Wang, JJ Liu, J Xia, J Liu, V Mirabella, ZP Pang - Cell reports, 2015 - cell.com
Summary Glucagon-like peptide-1 (GLP-1) and its analogs act as appetite suppressants and
have been proven to be clinically efficacious in reducing body weight in obese individuals …

Excess weight gain during the early postnatal period is associated with permanent reprogramming of brown adipose tissue adaptive thermogenesis

XQ Xiao, SM Williams, BE Grayson, MM Glavas… - …, 2007 - academic.oup.com
Excess weight gain during the early postnatal period increases the risk of persistent obesity
into adulthood and impacts on the subsequent risk for metabolic and cardiovascular …