[HTML][HTML] Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity
SJ Lee, G Sanchez-Watts, JP Krieger, A Pignalosa… - Molecular …, 2018 - Elsevier
Abstract Objective Glucagon-like peptide-1 (GLP-1) neurons in the hindbrain densely
innervate the dorsomedial hypothalamus (DMH), a nucleus strongly implicated in body …
innervate the dorsomedial hypothalamus (DMH), a nucleus strongly implicated in body …
Glucagon-like peptide-1 regulates brown adipose tissue thermogenesis via the gut-brain axis in rats
JP Krieger, EP Santos da Conceição… - American Journal …, 2018 - journals.physiology.org
Endogenous intestinal glucagon-like peptide-1 (GLP-1) controls satiation and glucose
metabolism via vagal afferent neurons (VANs). Recently, VANs have received increasing …
metabolism via vagal afferent neurons (VANs). Recently, VANs have received increasing …
Hypothalamic GLP-1: the control of BAT thermogenesis and browning of white fat
Brown adipose tissue (BAT) is a specialized organ responsible for thermogenesis, a process
required for maintaining body temperature. Since the discovery that BAT and brite/beige …
required for maintaining body temperature. Since the discovery that BAT and brite/beige …
Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling
SH Lockie, KM Heppner, N Chaudhary… - Diabetes, 2012 - Am Diabetes Assoc
We studied interscapular brown adipose tissue (iBAT) activity in wild-type (WT) and
glucagon-like peptide 1 receptor (GLP-1R)–deficient mice after the administration of the …
glucagon-like peptide 1 receptor (GLP-1R)–deficient mice after the administration of the …
[HTML][HTML] Glucagon, GLP-1 and thermogenesis
Brown adipose tissue (BAT) thermogenesis is a conserved mechanism to maintain body
temperature in mammals. However, since BAT contribution to energy expenditure can …
temperature in mammals. However, since BAT contribution to energy expenditure can …
[HTML][HTML] Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism
Objective Brown adipose tissue (BAT) thermogenesis is critical in maintaining body
temperature. The dorsomedial hypothalamus (DMH) integrates cutaneous thermosensory …
temperature. The dorsomedial hypothalamus (DMH) integrates cutaneous thermosensory …
[HTML][HTML] Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis
A Guilherme, DJ Pedersen, F Henriques… - Molecular …, 2018 - Elsevier
Objective Crosstalk between adipocytes and local neurons may be an important regulatory
mechanism to control energy homeostasis. We previously reported that perturbation of …
mechanism to control energy homeostasis. We previously reported that perturbation of …
[HTML][HTML] CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity
R Rodríguez-Rodríguez, C Miralpeix, A Fosch… - Molecular …, 2019 - Elsevier
Abstract Objective Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central
regulation of energy homeostasis. Our aim was to investigate whether CPT1C in the …
regulation of energy homeostasis. Our aim was to investigate whether CPT1C in the …
[HTML][HTML] Endogenous glucagon-like peptide-1 suppresses high-fat food intake by reducing synaptic drive onto mesolimbic dopamine neurons
Summary Glucagon-like peptide-1 (GLP-1) and its analogs act as appetite suppressants and
have been proven to be clinically efficacious in reducing body weight in obese individuals …
have been proven to be clinically efficacious in reducing body weight in obese individuals …
Excess weight gain during the early postnatal period is associated with permanent reprogramming of brown adipose tissue adaptive thermogenesis
XQ Xiao, SM Williams, BE Grayson, MM Glavas… - …, 2007 - academic.oup.com
Excess weight gain during the early postnatal period increases the risk of persistent obesity
into adulthood and impacts on the subsequent risk for metabolic and cardiovascular …
into adulthood and impacts on the subsequent risk for metabolic and cardiovascular …