Clonal expansion of infected CD4+ T cells is a major mechanism of HIV-1 persistence and a
barrier to achieving a cure. Potential causes are homeostatic proliferation, effects of HIV-1 …

Despite antiretroviral therapy (ART) which halts HIV-1 replication and reduces plasma viral
load to clinically undetectable levels, viral rebound inevitably occurs once ART is …

A latent reservoir for HIV-1 in resting CD4+ T lymphocytes precludes cure. Mechanisms
underlying reservoir stability are unclear. Recent studies suggest an unexpected degree of …

Antiretroviral therapy controls HIV replication but does not eliminate the virus from the
infected host. The persistence of a small pool of cells harboring integrated and replication …

HIV-1 infection is characterized by varying degrees of chronic immune activation and
disruption of T-cell homeostasis, which impact the rate of disease progression. A deeper …

Upon infection, HIV disseminates throughout the human body within 1–2 weeks. However,
its early cellular targets remain poorly characterized. We used a single-cell approach to …

The latent reservoir is a major barrier to HIV cure. As latently infected cells cannot be
phenotyped directly, the features of the in vivo reservoir have remained elusive. Here, we …

Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels to
below the limit of detection of clinical assays. However, even with prolonged suppression of …

The ability to persist long term in latently infected CD4 T cells represents a characteristic
feature of HIV-1 infection and the predominant barrier to efforts aiming at viral eradication …

The success of combination antiretroviral therapy for HIV-1 infection has generated interest
in mechanisms by which the virus can persist in the body despite the presence of drugs that …