The pre-hatching bovine embryo transforms the uterine luminal metabolite composition in vivo

M Sponchiado, AM Gonella-Diaza, CC Rocha… - Scientific reports, 2019 - nature.com
In cattle, conceptus development after elongation relies on well-characterized, paracrine
interactions with the hosting maternal reproductive tract. However, it was unrecognized …

Pre-hatching embryo-dependent and-independent programming of endometrial function in cattle

M Sponchiado, NS Gomes, PK Fontes, T Martins… - PloS one, 2017 - journals.plos.org
The bovine pre-implantation embryo secretes bioactive molecules from early development
stages, but effects on endometrial function are reported to start only after elongation. Here …

[HTML][HTML] Aspects of embryo-maternal communication in establishment of pregnancy in cattle

JM Sánchez, CA Simintiras, P Lonergan - Animal Reproduction, 2019 - SciELO Brasil
Establishment of pregnancy in mammals requires reciprocal molecular communication
between the conceptus and endometrium that modifies the endometrial transcriptome and …

Progesterone alters the bovine uterine fluid lipidome during the period of elongation

CA Simintiras, JM Sánchez, M McDonald… - …, 2019 - rep.bioscientifica.com
Successful bovine pregnancy establishment hinges on conceptus elongation, a key
reproductive phenomenon coinciding with the period during which most pregnancies fail …

Progesterone-dependent and progesterone-independent modulation of luminal epithelial transcription to support pregnancy in cattle

T Martins, M Sponchiado, FACC Silva… - Physiological …, 2022 - journals.physiology.org
In cattle, starting 4–5 days after estrus, preimplantation embryonic development occurs in
the confinement of the uterine lumen. Cells in the endometrial epithelial layer control the …

Changes in the uterine metabolome of the cow during the first 7 days after estrus

P Tríbulo, L Balzano‐Nogueira… - Molecular …, 2019 - Wiley Online Library
The uterine microenvironment during the first 7 days after ovulation accommodates and
facilitates sperm transit to the oviduct and constitutes the sole source of nutrients required for …

Blastocyst-induced changes in the bovine endometrial transcriptome

C Passaro, D Tutt, DJ Mathew, JM Sanchez… - …, 2018 - rep.bioscientifica.com
The objectives of this study were (i) to determine whether blastocyst-induced responses in
endometrial explants were detectable after 6-or 24-h co-culture in vitro;(ii) to test if direct …

Peri-estrus ovarian, uterine, and hormonal variables determine the uterine luminal fluid metabolome in beef heifers

FACC Silva, GF da Silva, BS Vieira… - Biology of …, 2021 - academic.oup.com
In cattle, uterine luminal fluid (ULF) is the main source of molecules that support embryo
development and survival during the peri-implantation period. Our overarching hypothesis is …

Analysis of the uterine epithelial and conceptus transcriptome and luminal fluid proteome during the peri-implantation period of pregnancy in sheep

K Brooks, GW Burns, JGN Moraes… - Biology of …, 2016 - academic.oup.com
Studies support the idea that uterine epithelia and their secretions have important biological
roles in conceptus survival, elongation, and implantation in sheep. The present study …

The influence of progesterone on bovine uterine fluid energy, nucleotide, vitamin, cofactor, peptide, and xenobiotic composition during the conceptus elongation …

CA Simintiras, JM Sánchez, M McDonald… - Scientific Reports, 2019 - nature.com
Conceptus elongation coincides with one of the periods of greatest pregnancy loss in cattle
and is characterized by rapid trophectoderm expansion, commencing~ Day 13 of …