[HTML][HTML] The emerging role of fatty acid binding protein 5 (FABP5) in cancers

WG Warren, M Osborn, A Yates, K Wright… - Drug Discovery …, 2023 - Elsevier
Highlights•Fatty acid binding protein 5 (FABP5) is a key regulator of cell metabolism and
growth that is overexpressed in cancers.•FABP5 facilitates the activation of transcriptional …

Therapeutic implications of FABP4 in cancer: an emerging target to tackle cancer

N Sun, X Zhao - Frontiers in Pharmacology, 2022 - frontiersin.org
Metabolic reprogramming is an emerging hallmark of tumor cells. In order to survive in
nutrient-deprived environment, tumor cells rewire their metabolic phenotype to provide …

The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells

A Slipicevic, K Jørgensen, M Skrede, AKR Rosnes… - BMC cancer, 2008 - Springer
Background The molecular mechanisms underlying melanoma tumor development and
progression are still not completely understood. One of the new candidates that emerged …

[HTML][HTML] Fatty acid binding protein 5 promotes metastatic potential of triple negative breast cancer cells through enhancing epidermal growth factor receptor stability

CA Powell, MW Nasser, H Zhao, JC Wochna, X Zhang… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Fatty acid binding protein 5 (FABP5), an intracellular lipid binding protein, has been shown
to play a role in various cancers, including breast cancer. However, FABP5 and its role in …

Role of FABP7 in tumor cell signaling

Y Kagawa, BA Umaru, I Ariful, SK Shil… - Advances in biological …, 2019 - Elsevier
Lipids are major molecules for the function of organisms and are involved in the
pathophysiology of various diseases. Fatty acids (FAs) signaling and their metabolism are …

High expression of fatty acid‐binding protein 5 promotes cell growth and metastatic potential of colorectal cancer cells

K Kawaguchi, S Senga, C Kubota, Y Kawamura… - FEBS open …, 2016 - Wiley Online Library
Fatty acid‐binding proteins (FABP s) are responsible for binding and storing hydrophobic
ligands such as long‐chain fatty acids, and for transporting these ligands to the appropriate …

Altered fatty acid‐binding protein 4 (FABP 4) expression and function in human and animal models of hepatocellular carcinoma

KJ Thompson, RG Austin, SS Nazari… - Liver …, 2018 - Wiley Online Library
Abstract Background and Aims Hepatocellular carcinoma (HCC) is the third leading cause of
cancer‐related mortality. Risk factors for developing HCC include viral hepatitis, alcohol and …

Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-κB) signaling in …

S Senga, N Kobayashi, K Kawaguchi, A Ando… - Biochimica et Biophysica …, 2018 - Elsevier
Fatty acid-binding proteins (FABPs) are involved in binding and storing hydrophobic ligands
such as long-chain fatty acids, as well as transporting them to the appropriate compartments …

FABP5 is correlated with poor prognosis and promotes tumour cell growth and metastasis in clear cell renal cell carcinoma

G Wu, Y Xu, Q Wang, J Li, L Li, C Han, Q Xia - European Journal of …, 2019 - Elsevier
To support proliferation, tumour cells often undergo a metabolic switch to aerobic glycolysis,
and a large amount of fatty acids (FAs) is produced to provide conditions for the formation of …

Expression of fatty acid binding protein 4 is involved in the cell growth of oral squamous cell carcinoma

D Lee, K Wada, Y Taniguchi… - Oncology …, 2014 - spandidos-publications.com
Fatty acid binding proteins (FABPs) are a family of small and highly conserved lipid
chaperone molecules with highly varied functions. Among them, fatty acid binding protein 4 …