Signals downstream of growth factor receptors play an important role in mammary
carcinogenesis. Recently, we demonstrated that the small GTPases ARF1 and ARF6 were …

Adhesion complex formation and disassembly is crucial for maintaining efficient cell
movement. During migration, several proteins act in concert to promote remodeling of the …

Invasion of tumor cells is a key step in metastasis that depends largely on the ability of these
cells to degrade the extracellular matrix. Although we have showed that the GTPase ADP …

Abstract The Small GTPase ADP-ribosylation factor 6 (Arf6) functions as the molecular
switch in cellular signaling pathways by cycling between GDP-bound inactive and GTP …

ADP-ribosylation factors (ARFs) are monomeric G proteins that regulate many cellular
processes such as reorganization of the actin cytoskeleton. We have previously shown that …

Activation of intracellular signaling pathways by growth factors is one of the major causes of
cancer development and progression. Recent studies have demonstrated that monomeric G …

Although several lines of evidence have shown that the small GTPase ADP-ribosylation
factor 6 (Arf6) plays pivotal roles in cancer progression of several types of cancers, little is …

The clinical use of EGFR-targeted therapy, in triple negative breast cancer patients, has
been limited by the development of resistance to these drugs. Although activated signaling …

ADP-ribosylation factor 4 (ARF4) is a member of the Ras superfamily of small guanine
nucleotide-binding proteins. ARF4 is known to interact with the epidermal growth factor …

Tumors are tissue‐specific diseases, and their mechanisms of invasion and metastasis are
highly diverse. In breast cancer, biomarkers that specifically correlate with the invasive …