Sex-specific impact of maternal obesity on fetal placental macrophages and cord blood triglycerides

LL Shook, KE James, DJ Roberts, CE Powe, RH Perlis… - Placenta, 2023 - Elsevier
Introduction Maternal obesity is associated with increased risk of offspring obesity and
cardiometabolic disease. Altered fetoplacental immune programming is a potential …

Maternal lipid levels across pregnancy impact the umbilical cord blood lipidome and infant birth weight

JL LaBarre, M Puttabyatappa, PXK Song… - Scientific reports, 2020 - nature.com
Major alterations in metabolism occur during pregnancy enabling the mother to provide
adequate nutrients to support infant development, affecting birth weight (BW) and potentially …

Maternal obesity alters placental lysophosphatidylcholines, lipid storage, and the expression of genes associated with lipid metabolism

KL Bidne, AL Rister, AR McCain, BD Hitt… - Biology of …, 2021 - academic.oup.com
Dyslipidemia is a characteristic of maternal obesity and previous studies have demonstrated
abnormalities in fatty acid oxidation and storage in term placentas. However, there is little …

Placental lipid transport and content in response to maternal overweight and gestational diabetes mellitus in human term placenta

L Song, N Wang, Y Peng, B Sun, W Cui - Nutrition, Metabolism and …, 2022 - Elsevier
Background and aims Placental lipid transport is altered in women with high prepregnancy
body mass index (pre-BMI) or gestational diabetes (GDM), which consequently affects foetal …

Modulation of fatty acid transport and metabolism by maternal obesity in the human full-term placenta

E Dubé, A Gravel, C Martin, G Desparois… - Biology of …, 2012 - academic.oup.com
Abstract Knowledge of the consequences of maternal obesity in human placental fatty acids
(FA) transport and metabolism is limited. Animal studies suggest that placental uptake of …

[HTML][HTML] The pathologic changes of human placental macrophages in women with hyperglycemia in pregnancy

J Ning, M Zhang, D Cui, H Yang - Placenta, 2022 - Elsevier
As the most common complication of pregnancy, hyperglycemia has a profound impact on
maternal and fetal health and the long-term development of the offspring. Placental …

Feto-placental adaptations to maternal obesity in the baboon

D Farley, ME Tejero, AG Comuzzie, PB Higgins, L Cox… - Placenta, 2009 - Elsevier
Maternal obesity is present in 20–34% of pregnant women and has been associated with
both intrauterine growth restriction and large-for-gestational age fetuses. While fetal and …

Obesity and maternal-placental-fetal immunology and health

M Monaco-Brown, DA Lawrence - Frontiers in pediatrics, 2022 - frontiersin.org
Obesity rates in women of childbearing age is now at 29%, according to recent CDC reports.
It is known that obesity is associated with oxidative stress and inflammation, including …

Maternal blood lipid profile during pregnancy and associations with child adiposity: findings from the ROLO study

AA Geraghty, G Alberdi, EJ O'Sullivan, EC O'Brien… - PloS one, 2016 - journals.plos.org
Background The in-utero environment affects fetal development; it is vital to understand how
maternal diet during pregnancy influences childhood body composition. While research …

Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta

JC Challier, S Basu, T Bintein, J Minium, K Hotmire… - Placenta, 2008 - Elsevier
Obesity and pregnancy are associated with a combination of insulin resistance and
inflammatory changes which exacerbate in combination. Based on the similarity between …