Mechanisms of flavonoid protection against myocardial ischemia–reperfusion injury

M Akhlaghi, B Bandy - Journal of molecular and cellular cardiology, 2009 - Elsevier
Flavonoids have long been acknowledged for their unique antioxidant properties, and
possess other activities that may be relevant to heart ischemia–reperfusion. They may …

Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes

WT Chang, ZH Shao, JJ Yin, S Mehendale… - European journal of …, 2007 - Elsevier
Since flavonoids scavenge reactive oxygen species, they may potentially protect against
ischemia/reperfusion injury. This study compared the scavenging capacity of specific …

[HTML][HTML] Flavonoids in myocardial ischemia-reperfusion injury: Therapeutic effects and mechanisms

J Jia, E Zang, L Lv, Q Li, C Zhang, Y Xia, L Zhang… - Chinese Herbal …, 2021 - Elsevier
Ischemic heart diseases are one of the major causes of death worldwide. Effective
restoration of blood flow can significantly improve patients' quality of life and reduce …

Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity

P Mladěnka, L Zatloukalová, T Filipský… - Free Radical Biology and …, 2010 - Elsevier
Epidemiological, as well as most in vivo, studies suggest that flavonoids have a positive
influence on various cardiovascular diseases. Traditionally, these effects were only …

Flavonoids and mitochondrial pharmacology: A new paradigm for cardioprotection

L Testai - Life sciences, 2015 - Elsevier
Acute myocardial ischemia is one of the major causes of illness and of deaths in Western
society; therefore the definition of the signaling pathways involved in the cardioprotection …

Botanical flavonoids on coronary heart disease

CZ Wang, SR Mehendale, T Calway… - The American journal of …, 2011 - World Scientific
Ischemic heart disease (IHD) is one of the leading causes of death in Western countries.
Prevention rather than treatment of heart disease can significantly improve patients' quality …

Cardioprotective effects of different flavonoids against myocardial ischaemia/reperfusion injury in Langendorff-perfused rat hearts

L Testai, A Martelli, M Cristofaro… - Journal of Pharmacy …, 2013 - academic.oup.com
Objective Flavonoids are important components of 'functional foods', with beneficial effects
on the cardiovascular function, mainly due to their antioxidant activity. Many flavonoids exert …

[HTML][HTML] Dietary flavonoids: Cardioprotective potential with antioxidant effects and their pharmacokinetic, toxicological and therapeutic concerns

J Khan, PK Deb, S Priya, KD Medina, R Devi… - Molecules, 2021 - mdpi.com
Flavonoids comprise a large group of structurally diverse polyphenolic compounds of plant
origin and are abundantly found in human diet such as fruits, vegetables, grains, tea, dairy …

[HTML][HTML] Antioxidant cardioprotection against reperfusion injury: potential therapeutic roles of resveratrol and quercetin

R Rodrigo, C Retamal, D Schupper… - Molecules, 2022 - mdpi.com
Ischemia-reperfusion myocardial damage is a paradoxical tissue injury occurring during
percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) patients …

[HTML][HTML] Protective mechanisms of quercetin against myocardial ischemia reperfusion injury

YM Zhang, ZY Zhang, RX Wang - Frontiers in Physiology, 2020 - frontiersin.org
Quercetin has attracted more attention in recent years due to its protective role against
ischemia/reperfusion injury. Quercetin can alleviate oxidative stress injury through the …