Pyroptosis refers to the process of gasdermin (GSDM)‐mediated programmed cell death
(PCD). Our understanding of pyroptosis has expanded beyond cells and is known to involve …

Pyroptosis is a necrotic form of regulated cell death. Gasdermines (GSDMs) are a family of
intracellular proteins that execute pyroptosis. While GSDMs are expressed as inactive forms …

Chemotherapy drugs usually inhibit tumor cell growth through the apoptosis pathway.
However, tumor cells become resistant to chemotherapy drugs by evading apoptosis. It is …

Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered
by inflammasomes and executed by gasdermin proteins. The main characteristics of …

The goal of cancer immunotherapy is to clear tumor cells by activating antitumor immunity,
especially by mobilizing tumor-reactive CD8+ T cells. Pyroptosis, programmed lytic cell …

Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two
major contributors to poor therapeutic responses during cancer intervention. Pyroptosis, a …

Pyroptosis, a type of inflammatory programmed cell death, is triggered by caspase cleavage
of gasdermin family proteins. Based on accumulating evidence, pyroptosis is closely …

Canonically, gasdermin D (GSDMD) cleavage by caspase-1 through inflammasome
signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen …

Pyroptosis is a programmed necrotic cell death mediated by pore-forming Gasdermin
(GSDM) proteins. After being unleashed from the C-terminal auto-inhibitory domains by …

The impressive success of current cancer immunotherapy in some patients but lack of
effectiveness in most patients suggests that additional strategies to promote antitumor …