Molecular mechanisms of apoptosis and cell selectivity of zinc dithiocarbamates functionalized with hydroxyethyl substituents

YS Tan, KK Ooi, KP Ang, AM Akim, YK Cheah… - Journal of inorganic …, 2015 - Elsevier
In the solid state each of three binuclear zinc dithiocarbamates bearing hydroxyethyl
groups,{Zn [S 2 CN (R) CH 2 CH 2 OH] 2} 2 for R= iPr (1), CH 2 CH 2 OH (2), and Me (3) …

Series of organotin (IV) compounds with different dithiocarbamate ligands induced cytotoxicity, apoptosis and cell cycle arrest on Jurkat E6. 1, T acute lymphoblastic …

NR Rasli, A Hamid, N Awang, NF Kamaludin - Molecules, 2023 - mdpi.com
The discovery of cisplatin has influenced scientists to study the anticancer properties of other
metal complexes. Organotin (IV) dithiocarbamate compounds are gaining attention as …

Discovery of novel chalcone-dithiocarbamates as ROS-mediated apoptosis inducers by inhibiting catalase

DJ Fu, JH Li, JJ Yang, P Li, YB Zhang, S Liu, ZR Li… - Bioorganic …, 2019 - Elsevier
Novel chalcone-dithiocarbamate hybrids were designed, synthesized and evaluated for
antiproliferative activity against selected cancer cell lines (MGC803, MCF7, and PC3) …

[HTML][HTML] A novel dithiocarbamate derivative induces cell apoptosis through p53-dependent intrinsic pathway and suppresses the expression of the E6 oncogene of …

Y Li, H Qi, X Li, X Hou, X Lu, X Xiao - Apoptosis, 2015 - Springer
Dithiocarbamates (DTCs) exhibit a broad spectrum of antitumor activities, however, their
molecular mechanisms of antitumor have not yet been elucidated. Previously, we have …

Diphenyltin (IV) dithiocarbamate macrocyclic scaffolds as potent apoptosis inducers for human cancer HEP 3B and IMR 32 cells: synthesis, spectral characterization …

R Kadu, H Roy, VK Singh - Applied Organometallic Chemistry, 2015 - Wiley Online Library
Binuclear diphenyltin (IV) dithiocabamate macrocyclic complexes [(Ph2SnIV) 2‐μ2‐bis
{(κ2S, S‐S2CN (R) CH2CONHC6H4) 2O}](R= iPr (1), sBu (2), nBu (3), Cy (4), 2‐furfuryl (5) …

Cytotoxicity evaluation and the mode of cell death of K562 cells induced by organotin (IV)(2-methoxyethyl) methyldithiocarbamate compounds

NF Kamaludin, N Ismail, N Awang… - Journal of Applied …, 2019 - japsonline.com
Two new organotin (IV) dithiocarbamate compounds, which are diphenyltin (IV)(2-
methoxyethyl) methyldithiocarbamate (compound 1) and triphenyltin (IV)(2-methoxyethyl) …

Discovery of novel heteroarylmethylcarbamodithioates as potent anticancer agents: Synthesis, structure-activity relationship analysis and biological evaluation

YB Li, X Yan, RD Li, P Liu, SQ Sun, X Wang… - European Journal of …, 2016 - Elsevier
A series of new analogs based on the structure of lead compound 10 were designed,
synthesized and evaluated for their in vitro anti-cancer activities against four selected human …

A bismuth diethyldithiocarbamate compound promotes apoptosis in HepG2 carcinoma, cell cycle arrest and inhibits cell invasion through modulation of the NF-κB …

DHA Ishak, KK Ooi, KP Ang, AM Akim… - Journal of inorganic …, 2014 - Elsevier
The compound with R= CH 2 CH 3 in Bi (S 2 CNR 2) 3 (1) is highly cytotoxic against a range
of human carcinoma, whereas that with R= CH 2 CH 2 OH (2) is considerably less so. Both 1 …

Synthesis and characterization of organotin complexes with dithiocarbamates and crystal structures of (4‐NCC6H4CH2) 2Sn (S2CNEt2) 2 and (2‐ClC6H4CH2) 2 Sn …

HD Yin, SC Xue - Applied organometallic chemistry, 2006 - Wiley Online Library
Ten organotin derivatives with dithiocarbamates of the formulae (4‐NCC6H4CH2) 2Sn
(S2CNEt2) 2 (1),(4‐NCC6H4CH2) 2Sn (S2CNBz2) 2 (2),(4‐NCC6H4CH2) 2Sn [S2CN …

[PDF][PDF] Cytotoxicity assessment of organotin (IV)(2-metoxyethyl) methyldithiocarbamate compounds in human leukemia cell lines

NF Kamaludin, SA Zakaria, N Awang… - Oriental Journal of …, 2017 - pdfs.semanticscholar.org
AbSTRACT Dibutyltin (IV)(2-methoxyethyl) methyldithiocarbamate (Compound 1) and
tricyclohexyltin (IV)(2-methoxyethyl) methyldithiocarbamate (Compound 2) were used to …