Significance: Modulation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated
antioxidant response is a key aspect in the onset of diabetes-related cardiovascular …

Endothelial dysfunction (ED) is a key event in the onset and progression of vascular
complications associated with diabetes. Regulation of endothelial function and the …

Abstract Type 2 diabetes (T2D) is a metabolic disease that is attributed to a combination of
genetic, lifestyle and environmental factors. There is compelling evidence that oxidative …

Interactive relationships between metabolism, inflammation, oxidative stress, and autophagy
in the vascular system play a key role in the pathogenesis of diabetic cardiovascular …

Diabetes is increasing at an alarming rate and, despite anti-hypertensive and insulin
therapies, diabetic patients are still at risk of developing complications such as chronic …

The pathogenic processes involving in the development of diabetes range from autoimmune
destruction of pancreatic β-cells with consequent insulin deficiency to abnormalities that …

Oxidative stress and inflammation are pathological processes involved in the genesis and
development of numerous disorders. Nuclear factor erythroid 2–related factor 2 (Nrf2) is a …

Cardiovascular diseases (CVD) are a group of cardiac and vascular disorders including
myocardial ischemia, congenital heart disease, heart failure, hypertension, atherosclerosis …

Diabetes is a chronic disease that induces many comorbidities, including cardiovascular
disease, nephropathy, and liver damage. Many mechanisms have been suggested as to …

Oxidative stress and inflammation are the mediators of diabetes and related secondary
complications. Oxidative stress arises because of the excessive production of reactive …