Increased epithelial cell expression of the cyclooxgenase-2 (COX-2) enzyme is a
characteristic event of both inflammatory bowel disease and colon cancer. We here report …

Inflammatory bowel diseases (IBD) are linked to an increased risk of developing colon
cancer, by inflammatory mediators and alterations to the extracellular matrix (ECM). The …

CD47 is a ubiquitously expressed transmembrane glycoprotein that regulates inflammatory
responses and tissue repair. Here, we show that normal mice treated with anti-CD47 …

Recently, enhanced CD146 expression was reported on endothelial cells in intestinal
biopsies from patients with inflammatory bowel disease. However, the underlying …

Background & Aims Overexpression of CD151 is associated with poor prognosis for
hepatocellular carcinoma (HCC), yet its role in pathogenesis is not known. Methods We …

Anomalies in the regulation and function of integrins have been implicated in the etiology of
various pathologic conditions, including inflammatory disorders such as irritable bowel …

CD47 deficient mice are resistant to dextran sulfate sodium (DSS)-induced experimental
colitis. The underlying mechanism, however, remains incompletely understood. In this study …

Abstract Treatment of Caco‐2‐BB e intestinal epithelial cells (BB e) with TNF‐α and
lymphotoxin‐β (LT‐β) receptor agonists induced the expression of the TNF receptor …

Transepithelial migration of neutrophils (PMN) is a defining characteristic of active
inflammatory states of mucosal surfaces. The process of PMN transepithelial migration …

Growing evidence that epithelial CD98 plays an important role in intestinal inflammation
focused our interest to investigate the transcriptional regulation of CD98. Our mouse-based …