The development of omics sciences has been greatly influenced by sequencing
technologies. However, the large volume of data generated by these technologies …

A plethora of algorithmic assemblers have been proposed for the de novo assembly of
genomes, however, no individual assembler guarantees the optimal assembly for diverse …

De novo genome assembly is the process of reconstructing a complete genomic sequence
from countless small sequencing reads. Due to the complexity of this task, numerous …

Bacterial genomes are simpler than mammalian ones, and yet assembling the former from
the data currently generated by high-throughput short-read sequencing machines still …

Abstract Next Generation Sequencing has totally changed genomics: we are able to
produce huge amounts of data at an incredibly low cost compared to Sanger sequencing …

Technologies for next-generation sequencing (NGS) have stimulated an exponential rise in
high-throughput sequencing projects and resulted in the development of new read …

Motivation De novo genome assembly is a challenging computational problem due to the
high repetitive content of eukaryotic genomes and the imperfections of sequencing …

Genome assembly is a process where large contigs and scaffolds are constructed from raw
reads generated by sequencing machines. Based on the size of the generated reads they …

Motivation: De novo assembly of a eukaryotic genome with next-generation sequencing
data is still a challenging task. Over the past few years several assemblers have been …

Background With the cost reduction of the next-generation sequencing (NGS) technologies,
genomics has provided us with an unprecedented opportunity to understand fundamental …