Non-muscle myosin II takes centre stage in cell adhesion and migration

M Vicente-Manzanares, X Ma, RS Adelstein… - … reviews Molecular cell …, 2009 - nature.com
Non-muscle myosin II (NM II) is an actin-binding protein that has actin cross-linking and
contractile properties and is regulated by the phosphorylation of its light and heavy chains …

Nonmuscle myosin II isoform and domain specificity during early mouse development

A Wang, X Ma, MA Conti, C Liu… - Proceedings of the …, 2010 - National Acad Sciences
Nonmuscle myosins (NMs) II-A and II-B are essential for embryonic mouse development, but
their specific roles are not completely defined. Here we examine the isoforms and their …

Nonmuscle myosin II moves in new directions

MA Conti, RS Adelstein - Journal of cell science, 2008 - journals.biologists.com
For many years, analyses of the role of the actomyosin cytoskeleton in many basic cellular
processes have centered on actin. Increasingly, however, a number of investigators are …

Nonmuscle myosin II isoforms coassemble in living cells

JR Beach, L Shao, K Remmert, D Li, E Betzig… - Current Biology, 2014 - cell.com
Summary Nonmuscle myosin II (NM II) powers myriad developmental and cellular
processes, including embryogenesis, cell migration, and cytokinesis [1]. To exert its …

Endogenous species of mammalian nonmuscle myosin IIA and IIB include activated monomers and heteropolymers

MS Shutova, WA Spessott, CG Giraudo, T Svitkina - Current Biology, 2014 - cell.com
Background Class II myosins generate contractile forces in cells by polymerizing into bipolar
filaments and pulling on anchored actin filaments. Nonmuscle myosin II (NMII) plays central …

Nonmuscle myosin II regulation directs its multiple roles in cell migration and division

M Garrido-Casado, G Asensio-Juárez… - Annual review of cell …, 2021 - annualreviews.org
Nonmuscle myosin II (NMII) is a multimeric protein complex that generates most mechanical
force in eukaryotic cells. NMII function is controlled at three main levels. The first level …

Myosin II isoforms play distinct roles in adherens junction biogenesis

ML Heuze, GHN Sankara Narayana, J d'Alessandro… - Elife, 2019 - elifesciences.org
Adherens junction (AJ) assembly under force is essential for many biological processes like
epithelial monolayer bending, collective cell migration, cell extrusion and wound healing …

Non-muscle myosin II in disease: mechanisms and therapeutic opportunities

KA Newell-Litwa, R Horwitz… - Disease models & …, 2015 - journals.biologists.com
The actin motor protein non-muscle myosin II (NMII) acts as a master regulator of cell
morphology, with a role in several essential cellular processes, including cell migration and …

Characterization of three full-length human nonmuscle myosin II paralogs

N Billington, A Wang, J Mao, RS Adelstein… - Journal of Biological …, 2013 - ASBMB
Nonmuscle myosin IIs (NM IIs) are a group of molecular motors involved in a wide variety of
cellular processes including cytokinesis, migration, and control of cell morphology. There …

Nonmuscle myosin IIA-dependent force inhibits cell spreading and drives F-actin flow

Y Cai, N Biais, G Giannone, M Tanase, G Jiang… - Biophysical journal, 2006 - cell.com
Abstract Nonmuscle myosin IIA (NMM-IIA) is involved in the formation of focal adhesions and
neurite retraction. However, the role of NMM-IIA in these functions remains largely unknown …