Selenium (Se) and its compounds have been reported to have great potential in the
prevention and treatment of Alzheimer's disease (AD). However, little is known about the …

The brain has a very high oxygen consumption rate and is particularly sensitive to oxidative
stress. It is also the last organ to suffer from a loss of selenium (Se) in case of deficiency. Se …

Selenoproteins are important for normal brain function, and decreased function of
selenoproteins can lead to impaired cognitive function and neurological disorders. This …

Fifty years have passed since the discovery of the first selenoprotein by Rotruck and
colleagues. In that time, the essential nature of selenium has come to light including the …

Selenium (Se) is an essential trace mineral mediating its biological function primarily
through selenoproteins. Accumulated lines of evidence indicate important roles of …

Expression of selenoproteins is widespread in neurons of the central nervous system. There
is continuous evidence presented over decades that low levels of selenium or …

Multiple biological functions of selenium manifest themselves mainly via 25 selenoproteins
that have selenocysteine at their active centre. Selenium is vital for the brain and seems to …

It is unsurprising that our understanding of the role of selenium in neurological function is
somewhat immature, considering its relatively recent discovery as an essential element to …

Although dietary selenium (Se) deficiency results in phenotypes associated with
selenoprotein depletion in various organs, the brain is protected from Se loss. To address …

Eighteen years ago, unexpected epileptic seizures in Selenop-knockout mice pointed to a
potentially novel, possibly underestimated, and previously difficult to study role of selenium …