Mesenchymal stem cells have neuroprotective effects that limit damage to the retina and
photoreceptors, and which may be mediated by extracellular vesicles (or exosomes) …

Background Retinal and/or optic nerve injury is one of the leading causes of blindness due
to retinal ganglion cell (RGC) degeneration. There have been extensive efforts to suppress …

Glaucoma is the leading cause of irreversible blindness worldwide, and pathologically
elevated intraocular pressure (IOP) is the major risk factor. Neuroprotection is one of the …

Glaucoma is characterized by progressive, irreversible damage to the retinal ganglion cells
(RGCs) and their axons. Our previous study has shown that the intravitreal transplantation of …

The development of neuroprotective strategies to attenuate retinal ganglion cell death could
lead to novel therapies for chronic optic neuropathies such as glaucoma. Intravitreal …

Purpose: To determine if bone marrow-derived stem cell (BMSC) small extracellular vesicles
(sEV) promote retinal ganglion cell (RGC) neuroprotection in the genetic DBA/2J mouse …

Traumatic optic neuropathy results in the loss of retinal ganglion cells (RGCs), leading to
unavoidable visual impairment. However, there is no effective therapy by far. Accumulated …

Purpose: The purpose of this study is to investigate the potential therapeutic benefits of
intravitreally transplanted human umbilical cord mesenchymal stem cells (UC-MSCs) in an …

Purpose.: Retrograde neurotrophic factor transport blockade has been implicated in the
pathophysiology of glaucoma. Stem cell transplantation appears to ameliorate some …

Retinal ischemia is a major cause of vision loss and impairment and a common underlying
mechanism associated with diseases such as glaucoma, diabetic retinopathy, and central …