Cell surface proteoglycans are known to be important regulators of many aspects of cell
behavior. The principal family of transmembrane proteoglycans is the syndecans, of which …

Syndecans form a family of cell surface proteoglycans, which can interact with various
effector molecules, such as extracellular matrix (ECM) molecules and growth factors …

Abstract Syndecan-1 (CD138), a cell-surface heparan sulfate proteoglycan, is involved in
cell–cell, cell-matrix interaction and growth factor binding. Loss of expression of syndecan-1 …

Syndecans are integral membrane proteoglycans characterized by the similarity of
cytoplasmic and transmembrane domains of the core proteins. Syndecans may regulate cell …

Syndecan-2 is a transmembrane heparan sulfate proteoglycan whose function at the cell
surface is unclear. In this study, we examined the function of syndecan-2 in colon cancer cell …

Syndecan‐1, a cell surface heparan sulfate proteoglycan, is critically involved in the
differentiation and prognosis of various tumors. In this review, we highlight the synthesis …

The process of metastasis involves a series of sequential steps in which malignant cells are
released from the primary tumor and metastasize to distant sites. Syndecan-1 is a cell …

Syndecans comprise a gene family of transmembrane proteoglycans that regulate cellular
behavior through interactions with various effectors, including heparin‐binding growth …

Syndecan proteoglycans may be key regulators of tumor invasion and metastasis because
this four-member family of transmembrane receptors regulates cell adhesion, proliferation …

Syndecans, a family of cell-surface proteoglycans of which syndecan-1 is the prototypical
member, play an important role in limiting tumor growth and invasive capacity through their …