Molecular Mechanisms of Clozapine-Induced Pancreatic Damage and its Modulation by L-Carnitine in a Rat Model

DIA Mesallam, E Ahmed Alaa El-Din… - Egyptian Society of …, 2024 - journals.ekb.eg
Background: Clozapine (CLZ) has been considered the mainstay drug in treatment of
resistant schizophrenia. Diabetes mellitus has befallen during clozapine therapy. L-carnitine …

CLOZAPINE-INDUCED MYOCARDITIS IN RATS: ROLE OF L-CARNITINE IN PROTECTION

MF Abbas, AH Abbas - The Egyptian Journal of Forensic …, 2016 - ejfsat.journals.ekb.eg
Clozapine (CLZ) is an atypical antipsychotic and often used in refractory schizophrenia. The
present study was carried out to investigate clozapine-induced myocarditis in albio rats and …

[PDF][PDF] The clozapine-induced toxicity via induction of oxidative stress and mitochondrial dysfunction in human blood lymphocytes and protecting role of l-carnitine

J Pourahmad, A Salimi, F Imani… - International …, 2020 - journals.sbmu.ac.ir
Clozapine is a useful antipsychotic drug but with serious, life threatening toxicity effects. The
aim of this study is to assess the direct cytotoxicity effect of clozapine (CLZ) on human blood …

Acetyl‐l‐Carnitine Ameliorates Caerulein‐induced Acute Pancreatitis in Rats

HMM Arafa, RAM Hemeida, MIA Hassan… - Basic & clinical …, 2009 - Wiley Online Library
In the present study, we have addressed the possible protective role of acetyl‐l‐carnitine in
caerulein‐induced acute pancreatitis in male Swiss albino rats. Acute pancreatitis paradigm …

Lambda-cyhalothrin-induced pancreatic toxicity in adult albino rats

S Sakr, WA Rashad - Scientific Reports, 2023 - nature.com
Lambda-cyhalothrin (LCT) is one of the most frequently utilized pyrethroids. This study
aimed to explore the toxic effects of subacute exposure to LCT on the pancreas and the …

The Histopathologic Effects of l-Carnitine in a Sodium Taurocholate–Induced Severe Pancreatitis Model

M Karakahya, M Gül, S Işık, C Aydın… - International …, 2016 - meridian.allenpress.com
This study aims to evaluate the histopathologic effects of l-carnitine (LC) in an experimental
severe pancreatitis (SP) model induced with sodium taurocholate. LC is an amino acid–like …

Possible mechanisms mediating the protective effect of cilostazol in L-arginine induced acute pancreatitis in rats: role of cGMP, cAMP, and HO-1

AM Abdel-Aziz, RA Rifaai, SA Abdel-Gaber - … -Schmiedeberg's Archives of …, 2020 - Springer
Acute pancreatitis (AP) is an inflammatory disorder with a high mortality rate. Cilostazol is a
selective phosphodiesterase-3 inhibitor drug that is commonly used as an antiplatelet …

[PDF][PDF] High-fat diet aggravates islet beta-cell toxicity in mice treated with clozapine

CH Huang, SH Fu, S Hsu, YY Huang… - … Gung Med J, 2012 - biomedj.cgu.edu.tw
Background: Clozapine, an atypical antipsychotic drug, induces derangements in glucose
homeostasis in certain patients. This study investigated the mechanisms of clozapine …

Protective effects of coenzyme Q10 and L-carnitine against statin-induced pancreatic mitochondrial toxicity in rats

M Sadighara, JP Joktaji, V Hajhashemi… - Research in …, 2017 - journals.lww.com
Statins are widely used in patients with hyperlipidemia and whom with high risk of
cardiovascular diseases. Unfortunately, statins also exert some adverse effects on the liver …

Carvedilol attenuates l-arginine induced acute pancreatitis in rats through modulation of oxidative stress and inflammatory mediators

EM El Morsy, MAE Ahmed - Chemico-biological interactions, 2020 - Elsevier
Acute pancreatitis (AP) is a sudden pancreatic inflammation accompanied by an excessive
reactive oxygen species production that provokes inflammation. The present study …