B cells play a central role in the immunopathogenesis of glomerulonephritides and
transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple …

B cells have a central role in many autoimmune diseases, including in those with renal
involvement, as well as in the immunological response to kidney transplantation. The …

Kidney transplantation is the optimal treatment for end-stage renal diseases. Although great
improvement has been achieved, immune tolerance is still the Holy Grail that every organ …

Whereas a B cell–transcriptional profile has been recorded for operationally tolerant kidney
graft patients, the role that B cells have in this tolerance has not been reported. In this study …

Human B cells with immunoregulatory properties in vitro (Bregs) have been defined by the
expression of IL-10 and are enriched in various B-cell subsets. However, proinflammatory …

Abstract Antibody-mediated rejection (AMR), including chronic AMR (cAMR), causes~ 50%
of kidney allograft losses each year. Despite attempts to develop well-tolerated and effective …

Intrarenal B cells in human renal allografts indicate transplant recipients with a poor
prognosis, but how these cells contribute to rejection is unclear. Here we show using single …

B lymphocytes are part of the inflammatory cells recruited to the human kidney in various
disease settings. B cell infiltrates have been described in renal allografts, in acute and …

Early immunological biomarkers that predict rejection and chronic allograft loss are needed
to inform preemptive therapy and improve long-term outcomes. Here, we prospectively …

Recent cross-sectional studies suggest an important role for transitional B lymphocytes
(CD19+ CD24hiCD38hi) in promoting transplant tolerance, and protecting from late antibody …