In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …

Mitotic spindle orientation is essential for cell fate decisions, epithelial maintenance, and
tissue morphogenesis. In most animal cell types, the dynein motor complex is anchored at …

Orientation of the cell division axis is essential for the correct development and maintenance
of tissue morphology, both for symmetric cell divisions and for the asymmetric distribution of …

The direction in which a cell divides is determined by the orientation of its mitotic spindle at
metaphase. Spindle orientation is therefore important for a wide range of developmental …

Correct positioning of the spindle governs placement of the cytokinesis furrow and thus
plays a crucial role in the partitioning of fate determinants and the disposition of daughter …

Correct spindle positioning is fundamental for proper cell division during development and
in stem cell lineages. Dynein and an evolutionarily conserved ternary complex (nuclear …

Correct alignment of the mitotic spindle during cell division is crucial for cell fate
determination, tissue organization, and development. Mutations causing brain diseases and …

The orientation of the mitotic spindle has been proposed to control cell fate choices, tissue
architecture, and tissue morphogenesis. Here, we review the mechanisms regulating the …

Cell division orientation during animal development can serve to correctly organize and
shape tissues, create cellular diversity or both. The underlying cellular mechanism is …

During development, the establishment of proper tissue architecture depends upon the
coordinated control of cell divisions not only in space and time, but also direction. Execution …